ACTH reduces the rise in ApoB-48 levels after fat intake

Skoog, Maria; Xu, N.; Berggren-Söderlund, Maria; Lovegrove, Julie A.; Nilsson‐Ehle, Peter

doi:10.1016/j.atherosclerosis.2006.05.012

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…In the present study we further confirmed our hypothesis that ACTH lowering apoB containing lipoproteins in humans mainly via the inhibition of hepatic apoB synthesis but not influence cellular lipid synthesis, which is compatible to our recent discovery that lipids was handled just as efficiently regardless of the reduced apoB secretion in response to ACTH administration, suggesting that fewer but more lipid rich lipoproteins are synthesised from the small intestine during ACTH influence [ 10 ].…”

Section: Discussionsupporting

confidence: 91%

“…The fact that secretion of de novo synthesised lipids was not restrained in parallel with reduced apoB output in HepG2 cells in response to ACTH has also bee seen in the human small intestine in vivo [ 10 ]. Although these systems of lipoprotein production may be different the secretory pathway for triglyceride rich lipoproteins in liver and intestine share several characteristics [ 24 - 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Further a pronounced and consistent decrease of plasma total cholesterol in particular LDL-cholesterol by 30-40% is seen after ACTH treatment in healthy individuals and in patients with secondary hyperlipidemia [ 5 - 9 ]. Plasma phospholipids are also significantly reduced and triglycerides are mainly lowered, especially in patients with initially high levels [ 5 , 6 , 8 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The hypothesis that ACTH reduced apoB output was further supported in vivo, by using the human postprandial phase to study the induced apoB48 production. In healthy humans ACTH significantly inhibited the transient rise in apoB48 in plasma, while the lipid handling, followed as triglycerides and retinyl palmitate, seemed unimpaired [ 10 ]. We hypothesised that ACTH induced the intestinal cells to produce larger, more lipid rich, but fewer lipoproteins.…”

Section: Introductionmentioning

confidence: 99%

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Lipid synthesis and secretion in HepG2 cells is not affected by ACTH

et al. 2010

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Apolipoprotein B (apoB) containing lipoproteins, i.e. VLDL, LDL and Lp(a), are consequently lowered by ACTH treatment in humans. This is also seen as reduced plasma apoB by 20-30% and total cholesterol by 30-40%, mostly accounted for by a decrease in LDL-cholesterol. Studies in hepatic cell line (HepG2) cells showed that apoB mRNA expression is reduced in response to ACTH incubation and is followed by a reduced apoB secretion, which may hypothesize that ACTH lowering apoB containing lipoproteins in humans may be mediated by the inhibition of hepatic apoB synthesis. This was recently confirmed in vivo in a human postprandial study, where ACTH reduced transient apoB48 elevation from the small intestine, however, the exogenic lipid turnover seemed unimpaired. In the present study we investigated if lipid synthesis and/or secretion in HepG2 cells were also affected by pharmacological levels of ACTH to accompany the reduced apoB output. HepG2 cells were incubated with radiolabelled precursors ([14C]acetate and [3H]glycerol) either before or during ACTH stimuli. Cellular and secreted lipids were extracted with chloroform:methanol and separated by the thin layer chromatography (TLC), and [14C]labelled cholesterol and cholesteryl ester and [3H]labelled triglycerides and phospholipids were quantitated by the liquid scintillation counting. It demonstrated that ACTH administration did not result in any significant change in neither synthesis nor secretion of the studied lipids, this regardless of presence or absence of oleic acid, which is known to stabilize apoB and enhance apoB production. The present study suggests that ACTH lowers plasma lipids in humans mainly mediated by the inhibition of apoB synthesis and did not via the reduced lipid synthesis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lipid synthesis and secretion in HepG2 cells is not affected by ACTH

et al. 2010

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“…Intake of dietary fibers (DF) from cereals etc., increase cholesterol and bile acids excretion rates lowering their bioavailability because they might act as bile acid scavengers. This mechanism impair bile acids re-absorption stimulating the hepatic synthesis of new bile acids from cholesterol reducing its blood concentration 10,60,61 although for particular β-glucans, modulation of cholesterol-related gene expresions have been also noticed 62 .…”

Section: Fungal Molecules Modulating Cholesterol Metabolismmentioning

confidence: 99%

Molecular actions of hypocholesterolaemic compounds from edible mushrooms

2018

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Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa. Nowadays, the commonly prescribed therapeutic treatments for hypocholesterolemic patients are targeted toward the reduction of both cholesterol intestinal absorption and/or its endogenous biosynthesis. But, when hypercholesterolemia is still moderate the consumption of food products with cholesterol-lowering capacities is more desirable than using drugs. Marketed foods supplemented with hypocholesterolemic compounds are only inhibiting mechanisms for cholesterol absorption (i.e. phytosterols and cereal β-glucans). However, certain fungal extracts obtained from edible mushrooms might be able to modulate cholesterol levels by both strategies, pharmaceutical drugs and functional foods. In vitro and in vivo studies indicated that fungal sterols down-regulated genes involved in cholesterol homeostasis (such as Srebf2 and Nr1h4 (FXR)) and other specific mushroom extracts (β-glucans and other water-soluble compounds) also stimulated transcriptional profiles similar to simvastatin or ezetimibe (two hypocholesterolemic drugs). These and other observations suggested that the hypocholesterolemic effect of mushroom extracts could be due to transcriptional and post-transcriptional modulations besides other indirect effects.

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2008

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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ACTH reduces the rise in ApoB-48 levels after fat intake

Cited by 5 publications

References 38 publications

Lipid synthesis and secretion in HepG2 cells is not affected by ACTH

Lipid synthesis and secretion in HepG2 cells is not affected by ACTH

Molecular actions of hypocholesterolaemic compounds from edible mushrooms

Current World Literature

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