Actigraphic and self-reported sleep quality in women: associations with ovarian hormones and mood

Li, David X.; Romans, Sarah; Souza, Mary Jane De; Murray, Brian J.; Einstein, Gillian

doi:10.1016/j.sleep.2015.06.009

Cited by 36 publications

(27 citation statements)

References 48 publications

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“…However, the hypnotic effect of progesterone has been demonstrated in the context of low estrogen states which differs from the hormonal profile in IVF. 53, 54 …”

Section: Prevalence and Evolution Of Sleep Disturbances During The IVmentioning

confidence: 99%

“…Although direct comparisons are not possible, as this is the first study to assess sleep objectively in women undergoing IVF, this finding is not surprising from a hormonal standpoint based on previous studies of sleep in reproductive age women. Multiple studies in naturally cycling women have assessed sleep with either actigraphy 54 or polysomnography 55-59 and demonstrate stability of SOL, SE, and TST despite the changing hormonal profiles through the follicular and luteal stages of the menstrual cycle. Caution must be used in equating the follicular stage of the menstrual cycle with controlled ovarian stimulation during IVF.…”

Section: Prevalence and Evolution Of Sleep Disturbances During The IVmentioning

confidence: 99%

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Sleep in women undergoing in vitro fertilization: a pilot study

et al. 2017

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Objective Sleep disturbances are thought to be frequent in women undergoing IVF despite minimal research of this hypothesis. Our goal was to longitudinally assess sleep duration and disturbances in women undergoing IVF and assess impact of habitual sleep duration on oocytes retrieved, an important outcome in IVF. Methods Actigraphy and questionnaire batteries containing sleep and psychometric instruments were performed prior to and throughout 24 IVF cycles. Results TST <7 hours was present in 46%, 57%, 69%, and 42% of baseline, stimulation, post-oocyte retrieval, and post-embryo transfer recordings. ESS>10 was noted in 24%, 33%, and 36% of cycles during baseline, stimulation, and post-embryo transfer. PSQI>5 was noted in 57%, 43%, and 29% of cycles during baseline, stimulation, and post-embryo transfer. TST (F=2.95, p=0.04) and ESS (F=4.36, p=0.02) were the only sleep metrics in which a significant main effect of time was found by mixed models analysis. The final linear regression model chosen by stepwise selection to best explain the variability in oocytes retrieved included anti-mullerian hormone, day 3 follicle stimulating hormone, and baseline TST and explained 40% of the variance in oocytes retrieved (adjusted R2=0.40, p=0.03). Although not statistically significant, a trend towards a linear association between baseline TST and oocytes retrieved was seen with an increase of oocytes retrieved by 1.5 for every hour increase in TST (p=.09). Conclusions This is the first study to describe, with subjective and objective measures, sleep disturbances present throughout the IVF cycle. Importantly, a trend towards a linear relationship between TST and oocytes retrieved was found in this pilot study. Sleep may be a modifiable target to improve outcomes in women undergoing IVF and further investigations are needed.

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“…However, the hypnotic effect of progesterone has been demonstrated in the context of low estrogen states which differs from the hormonal profile in IVF. 53, 54 …”

Section: Prevalence and Evolution Of Sleep Disturbances During The IVmentioning

confidence: 99%

Section: Prevalence and Evolution Of Sleep Disturbances During The IVmentioning

confidence: 99%

Sleep in women undergoing in vitro fertilization: a pilot study

et al. 2017

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“…More recently, abnormal Clock expression was found in spontaneously aborted mice fetuses [67,68]. Middle aged, but not young, Per mutant animals demonstrated frequent postimplantation pregnancy loss [86].…”

Section: Early Gestationmentioning

confidence: 99%

“…Interestingly, the predominant hormone during the luteal phase, progesterone, is a known GABA A receptor agonist [81] and exogenous administration increases sleep in post-menopausal women [25,94] and women in the early follicular phase [106]. Conversely, endogenous progesterone is associated with increased wake time during the sleep period [10,67,68] potentially due to elevation of core body temperature [79]. In particular, the speed of progesterone rise and progesterone increases in the presence of estrogen may underlie the association of progesterone with reduced sleep quality [96].…”

Section: Reproductive Hormonal Milieu Influences Sleepmentioning

confidence: 99%

“…Estrogen improves sleep in post-menopausal women and one investigation demonstrated a positive association between actigraphically recorded sleep efficiency and an estrogen metabolite [67,68]; conversely, a polysomnogram study demonstrated a positive association between wake after sleep onset and estrogen [10]. Therefore, the relationship between endogenous estrogen and sleep remains to be elucidated.…”

Section: Reproductive Hormonal Milieu Influences Sleepmentioning

confidence: 99%

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Sleep, Circadian Rhythms, and Fertility

Goldstein

Smith

2016

Curr Sleep Medicine Rep

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Adequate sleep is crucial for general health and wellbeing. Although the neuronal control of the reproductive axis and sleep-generating neurons share an anatomical location, little is known regarding the impact of sleep and circadian disruption on fertility in women. Animal models have established clear circadian control of the pre-ovulatory luteinizing hormone surge. Additionally, disruption of the circadian timing system by exposure to abnormal light-dark cycles or mutations of core clock genes results in diminished reproductive capacity in animals. Abnormalities in menstruation, fertility, and early pregnancy maintenance in female shift workers provide evidence for a role of circadian rhythms in the reproductive health of women. Reproductive hormones may modify sleep, and the relationship is bidirectional such that sleep disruption may alter the profile of reproductive hormone secretion. Therefore, sleep, apart from its circadian timing, may also have relevance in attaining pregnancy. Additionally, infertility is associated with psychological distress which may result in poor quality sleep. The interaction between psychological distress and disturbed sleep in reproduction has garnered minimal attention and may be a crucial factor to consider during the evaluation and treatment of infertility. This work reviews animal models and evidence in women that suggest a role for sleep and circadian rhythms in reproductive health and reveals areas that require future investigation.

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Yogic Sleep and Walking Protocol Induced Improvement in Sleep and Wellbeing in Post-menopausal Subject: A Longitudinal Case Study During COVID Lockdown

Gulia

Sreedharan

2021

Sleep Vigilance

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Actigraphic and self-reported sleep quality in women: associations with ovarian hormones and mood

Cited by 36 publications

References 48 publications

Sleep in women undergoing in vitro fertilization: a pilot study

Sleep in women undergoing in vitro fertilization: a pilot study

Sleep, Circadian Rhythms, and Fertility

Yogic Sleep and Walking Protocol Induced Improvement in Sleep and Wellbeing in Post-menopausal Subject: A Longitudinal Case Study During COVID Lockdown

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