Actin-induced reticuloendothelial phagocytic depression as mediated by its interaction with fibronectin

Dillon, Bruce C.; Estes, James E.; Saba, Thomas M.; Blumenstock, Frank A.; Cho, Eshin; Lee, S.K.; Lewis, Edward

doi:10.1016/0014-4800(83)90086-2

Cited by 21 publications

(11 citation statements)

References 15 publications

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“…3b). The highly immunoreac-tive fibronectin content in both cell mem brane and cytoplasm agrees with the known ability of macrophages to synthetize fibro nectin [26], which enhances phagocytosis [27]. However, in regard to Yoshida ascites sarcoma cells, the phagocytizing activity is considerably decreased, and, to be more pre cise, can be considered absent in as much as the phagocytic cells are probably the reactive macrophages usually present in the tumor population.…”

Section: Discussionsupporting

confidence: 55%

Cytochemical and Immunocytochemical Characterization of Yoshida Ascites Sarcoma Cells

Nicòtina¹,

Ruggeri²,

Ferlazzo³

et al. 1991

Tumor Biol

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Some cytochemical and immunocytochemical investigations were carried out on actively growing Yoshida ascites sarcoma cells. These cells displayed an intense granular α-naphthylacetate esterase (ANAE) staining while the α-naphthylbutyrate esterase (ANBE) reaction was in part fluoride-sensitive and marked particularly in the large-sized malignant cells. Acid phosphatase as well as peroxidase activities were not detected. The lack of immu-noreactive lysozyme and α₁-antitrypsin suggested a poor differentiation of the above-mentioned tumor cells, but fibronectin and S-100 protein where highly expressed, as in tumors arising from the mononuclear phagocyte system.

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Section: Discussionsupporting

confidence: 55%

Cytochemical and Immunocytochemical Characterization of Yoshida Ascites Sarcoma Cells

Nicòtina¹,

Ruggeri²,

Ferlazzo³

et al. 1991

Tumor Biol

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“…The interaction of actin with plasma proteins other than fibrin has not been examined quantitatively, though it has been suggested that actin may interact with fibronectin at sites of tissue injury (35).…”

Section: Discussionmentioning

confidence: 99%

Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation.

Lind¹,

Smith²,

Janmey³

et al. 1986

J. Clin. Invest.

152

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We determined the plasma kinetics of both actin and complexes of actin with the two high affinity actin-binding proteins of plasma, gelsolin, and vitamin D-binding protein (DBP). Actin is cleared rapidly from the plasma by the liver (half-disappearance time, 0.5 h). Using radiolabeled actin-binding proteins, we found that actin accelerated the clearance of both plasma gelsolin and the vitamin D-binding protein.In separate experiments we found that DBP-actin complexes were cleared more quickly than gelsolin-actin complexes, at a rate comparable to the clearance of actin from the blood. A low affinity interaction (dissociation constant, 2.9 X 10-M) between actin and fibronectin was found, suggesting that little actin will bind to fibronectin in plasma. We conclude that while plasma gelsolin and DBP may both clear actin from the circulation, DBP appears to play a more important role. By so doing, DBP may conserve the filament-severing activity of plasma gelsolin.

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“…Tissue fibronectin is antigenicaily related to plasma fibronectin, though there are differences in some of their properties. Fibronectin has a unique globu lar domain with high affinity for collagen, fibrin, heparin, actin, Clq and Staphylococ cus aureus [76][77][78][79], all of which are cleared by the phagocytic cells. Both plasma fibro nectin and plasma opsonic activity are re duced under certain pathological or nonphysiological conditions, e.g.…”

Section: Fibronectinmentioning

confidence: 99%

Phagocytosis: An Overview

Chakravarti

1987

Path Immunopathol Res

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Actin-induced reticuloendothelial phagocytic depression as mediated by its interaction with fibronectin

Cited by 21 publications

References 15 publications

Cytochemical and Immunocytochemical Characterization of Yoshida Ascites Sarcoma Cells

Cytochemical and Immunocytochemical Characterization of Yoshida Ascites Sarcoma Cells

Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation.

Phagocytosis: An Overview

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