Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement

Koubek, Emily J.; Santy, Lorraine C.

doi:10.3390/cells11223565

Cited by 11 publications

(3 citation statements)

References 79 publications

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“…DOCK1 is the most common binding partner for CRK. DOCK1 will activate Rac which will stimulate actin polymerization [31]. The pathogenesis model of bovine tuberculosis through the binding of MPB83 with β3 integrin can be seen in Fig.…”

Section: Discussionmentioning

confidence: 99%

Molecular Docking MPB83 Protein on β2, β3, and α5β1 Integrins: Pathogenesis of Bovine Tuberculosis in Humans

Rahmani

Rachmania

Mufida

2023

Preprint

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Tuberculosis is a chronic infectious disease caused by the Mycobacterium tuberculosis complex (MTBC). Two MTBC species that causes infection in human are Mycobacterium tuberculosis (M. tuberculosis) and Mycobacterium bovis (M. bovis). Bovine tuberculosis (bTB) is a zoonotic disease with 2.55 times higher mortality rate compared to tuberculosis due to M. tuberculosis. Mycobacterium infect humans through the bonding between adhesin molecules on the bacteria surface and fibronectin receptors on the human body such as β2, β3, and α5β1 integrins. β2, β3, and α5β1 integrins are responsible for migrating bacterial activity and strengthening cell adhesion. MPB83 is a bacterial surface protein expressed more by M. bovis than by M. tuberculosis. This study aims to examine the binding of MPB83 protein to β2, β3, and α5β1 integrins as potential pathogenesis of bTB in humans by molecular docking method. Molecular docking was carried out using ClusPro to determine the interaction between the MPB83 protein and β2, β3, and α5β1 integrins based on binding energy and binding interaction model. The results showed that in silico, bonds occur between MPB83 protein and β2, β3, and α5β1 integrins which can potential for the pathogenesis of bTB in humans.

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Section: Discussionmentioning

confidence: 99%

Molecular Docking MPB83 Protein on β2, β3, and α5β1 Integrins: Pathogenesis of Bovine Tuberculosis in Humans

Rahmani

Rachmania

Mufida

2023

Preprint

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“…Recently, other signaling factors regulating myoblast fusion have been identified. Dock1 promotes myoblast fusion through the activation of Rac1 [25]. The depletion of POFUT1 negatively affects secondary myogenic fusion by repressing NFATc2/IL4 signaling [26].…”

Section: Discussionmentioning

confidence: 99%

All-Trans Retinoic Acid-Responsive LGR6 Is Transiently Expressed during Myogenic Differentiation and Is Required for Myoblast Differentiation and Fusion

Kitakaze,

Tatsumi,

Yamaguchi

et al. 2023

IJMS

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All-trans retinoic acid (ATRA) promotes myoblast differentiation into myotubes. Leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is a candidate ATRA-responsive gene; however, its role in skeletal muscles remains unclear. Here, we demonstrated that during the differentiation of murine C2C12 myoblasts into myotubes, Lgr6 mRNA expression transiently increased before the increase in the expression of the mRNAs encoding myogenic regulatory factors, such as myogenin, myomaker, and myomerger. The loss of LGR6 decreased the differentiation and fusion indices. The exogenous expression of LGR6 up to 3 and 24 h after the induction of differentiation increased and decreased the mRNA levels of myogenin, myomaker, and myomerger, respectively. Lgr6 mRNA was transiently expressed after myogenic differentiation in the presence of a retinoic acid receptor α (RARα) agonist and an RARγ agonist in addition to ATRA, but not in the absence of ATRA. Furthermore, a proteasome inhibitor or Znfr3 knockdown increased exogenous LGR6 expression. The loss of LGR6 attenuated the Wnt/β-catenin signaling activity induced by Wnt3a alone or in combination with Wnt3a and R-spondin 2. These results indicate that LGR6 promotes myogenic differentiation and that ATRA is required for the transient expression of LGR6 during differentiation. Furthermore, LGR6 expression appeared to be downregulated by the ubiquitin–proteasome system involving ZNRF3.

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“…The protective effect of miR-598-3p inhibition on SEFL was probably through the regulation of the actin cytoskeleton, which is required for learning and plasticity. The actin cytoskeleton pathway is intertwined with many cellular processes, such as motility, adhesion, and proliferation [ 94 ]. It is worth noting that the actin cytoskeleton has been a major focus of neural injury and regeneration research.…”

Section: Dysregulated Mirnas In Ptsdmentioning

confidence: 99%

Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury

Zhu

Huang

et al. 2023

Mol Psychiatry

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Post-traumatic stress disorder (PTSD) is usually considered a psychiatric disorder upon emotional trauma. However, with the rising number of conflicts and traffic accidents around the world, the incidence of PTSD has skyrocketed along with traumatic brain injury (TBI), a complex neuropathological disease due to external physical force and is also the most common concurrent disease of PTSD. Recently, the overlap between PTSD and TBI is increasingly attracting attention, as it has the potential to stimulate the emergence of novel treatments for both conditions. Of note, treatments exploiting the microRNAs (miRNAs), a well-known class of small non-coding RNAs (ncRNAs), have rapidly gained momentum in many nervous system disorders, given the miRNAs’ multitudinous and key regulatory role in various biological processes, including neural development and normal functioning of the nervous system. Currently, a wealth of studies has elucidated the similarities of PTSD and TBI in pathophysiology and symptoms; however, there is a dearth of discussion with respect to miRNAs in both PTSD and TBI. In this review, we summarize the recent available studies of miRNAs in PTSD and TBI and discuss and highlight promising miRNAs therapeutics for both conditions in the future.

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Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement

Cited by 11 publications

References 79 publications

Molecular Docking MPB83 Protein on β2, β3, and α5β1 Integrins: Pathogenesis of Bovine Tuberculosis in Humans

Molecular Docking MPB83 Protein on β2, β3, and α5β1 Integrins: Pathogenesis of Bovine Tuberculosis in Humans

All-Trans Retinoic Acid-Responsive LGR6 Is Transiently Expressed during Myogenic Differentiation and Is Required for Myoblast Differentiation and Fusion

Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury

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