Actinic Cheilitis: Efficacy and Cosmetic Results

Abstract

Actinic cheilitis (AC) is a common disease caused by long-term solar exposure and is considered a premalignant lesion of the lips. AC has potential to develop into squamous cell carcinoma (SCC) and metastasis. SCC of the lip arising from AC is more prone to metastasis than cutaneous form with rates of the former varying between 3% and 20% and is the most common malignancy of the oral cavity. AC affects especially pale-skinned individuals with poorly pigmented lower lips. The overall survival rate in 5 years is less than 75%. Treatments are difficult because surgical treatment can have significant adverse effects, whereas less invasive procedures may not be as efficient. A high degree of clinical suspicion should be maintained, given the malignant nature of the condition. We emphasize the need for regular follow-up, rigorous clinical exam, and accurate pathologic analysis. The chapter will discuss the efficacy of therapy with photodynamic therapy (PDT) using methyl aminolevulinate and 5-aminolevulinic acid, application times, skin preparation techniques, pain, cosmetic outcome, and patient satisfaction.