Actinic Cheilitis Granulomatosa

Kuno, Yoshinori; Sakakibara, S; Mizuno, Nobuyuki

doi:10.1111/j.1346-8138.1992.tb03729.x

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…The etiology of CG has not been well established; however, several explanations have been proposed - including genetic predisposition and environmental exposures - that lead to dermal inflammation [1]. One case report proposed a possible role of UVB-photosensitivity in the pathogenesis of CG [3]. Moreover, the delayed type of hypersensitivity reaction has been implicated as an etiologic mechanism.…”

Section: Discussionmentioning

confidence: 99%

Unsuccessful Treatment of Cheilitis Granulomatosa with Oral Methotrexate

2019

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Cheilitis granulomatosa (CG) is a rare idiopathic condition with painless lip swelling, characterized by non-necrotizing granulomatous inﬂammation in the absence of other identifiable causes such as Crohn’s disease, sarcoidosis, foreign body reaction, or infection. CG may precede the presentation of Crohn’s disease after long-term follow-up. Spontaneous remission of CG rarely occurs. To date, given the rarity of CG, there is no gold standard treatment. Recommended treatments are supported by small studies, case reports/series, and expert opinions. Glucocorticoids are the first-line therapy in the acute stages of the disease; however, recurrence commonly occurs. Previously, methotrexate (MTX) showed a beneﬁcial effect on orofacial swelling in a case of CG accompanied by Crohn’s disease. We present a patient with CG without Crohn’s disease. He was treated with oral MTX in combination with intralesional corticosteroid injection on one side of the lip. The injected side showed improvement, while lip swelling on the noninjected area remained unchanged after 3 months of treatment. Therefore, CG is refractory to treatment with MTX from our experience. Further studies regarding the optimum dosage of MTX is needed.

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Section: Discussionmentioning

confidence: 99%

Unsuccessful Treatment of Cheilitis Granulomatosa with Oral Methotrexate

2019

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“…The results were evaluated at 30 min and at 24, 48, and 72 h after injection. 6.75 X 10 2j/m2 with System 1; this dose was the lower limit of the normal range from 6.75 x 10 2 j/m 2 to 1.8 x 10 3 j/m 2 (8). There was no abnormal elongation in the course of the erythematous reaction (9) nor did 1.2 x 10 5 j/m 2 of UVA light develop any visible skin reactions at 30 min or at 24 h, 48 h, or 72 h after irradiation with System 2.…”

Section: Intracutaneous Tests With Irradiatedmaterialsmentioning

confidence: 91%

Photocontact Allergy Due to Suprofen

Kuno

Numata

1994

The Journal of Dermatology

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A 79-year-old Japanese woman developed edematous erythema on sun-exposed areas 3 months after applying Sulprotin ointment, which contains 1% suprofen (SP), a phenylacetic acid derivative. A patch test with Sulprotin ointment as it was negative, but a photopatch test with Sulprotein ointment as is was positive. A photopatch test with 10-3% SP was positive, as was that obtained with an SP analogue, 3% ketoprofen, but that with the ointment base of Sulprotin was negative. Photopatch tests with other SP analogues such as flurbiprofen, ibuprofen, and pranoprofen were negative. She developed abnormal erythema with monochromatic irradiation in the range from 320 to 380 nm on the uninvolved abdominal skin where 1% SP had been applied 24 hours (h) before irradiation. The action spectrum for this erythema agreed with the absorption spectrum of SP in the range of UVA. The MED after applying SP was below that after applying w. pet. in the range from 250 to 290 nm and from 300 to 320 nm. Positive intracutaneous test results were obtained with an irradiated mixture of human serum albumin (HSA) and SP at 48 and 72 h after injection and negative ones with a mixture of HSA and irradiated SP.

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“…34,36 Granulomatous cheilitis can present with diffuse swelling of the lower lip and is often a manifestation of systemic disease. [37][38][39][40][41] A history of allergic reactions or of exposure to known toxic agents may suggest the diagnoses of allergic contact cheilitis or irritant contact cheilitis. 42 Perioral involvement may occur.…”

Section: Inflammatory and Eczematoid Disorders Of The Lower Lipmentioning

confidence: 99%