Actinic granuloma responding to doxycycline

A report of disseminated actinic granuloma: An unusually extensive presentation

“…Although ideal treatment remains unclear, therapeutic options include topical, intralesional, and systemic corticosteroids, as well as cryotherapy, topical and oral retinoids, topical calcineurin inhibitors, tetracyclines, dapsone, antimalarials, adalimumab, immunosuppressants, and laser therapy. 4,7,[11][12][13][14][15][16][17][18][19][20][21] While hydroxychloroquine has demonstrated efficacy in treating actinic granuloma in numerous reports; the patient described herein refused hydroxychloroquine treatment due to apprehension regarding adverse effects based on her perception of negative media coverage of the medication during the COVID-19 pandemic. 4,[19][20][21] While concern for hydroxychloroquine shortages was reported in the rheumatologic literature early in the pandemic, little is written about sensationalism associated with hydroxychloroquine during the COVID-19 pandemic and its potential to affect patients' future decision-making with respect to treatment with this drug for rheumatologic and dermatologic conditions.…”

Complete resolution of generalized annular elastolytic giant cell granuloma with doxycycline

“…Anti-inflammatory and anti-granulomatous effects of tetracyclines are well known but they are not regarded as a convenient treatment due to their phototoxicity and the seldom reported risk to trigger AEGCG. 2 Nevertheless, tetracyclines have shown excellent outcomes with complete responses in both limited 3 , 4 and generalized 5 forms involving sun-exposed and nonexposed skin with no side effects. Table 1 3 , 4 , 5 summarizes the main features of our patient and the three previously published cases of AEGCG treated with tetracyclines.…”

“… 2 Nevertheless, tetracyclines have shown excellent outcomes with complete responses in both limited 3 , 4 and generalized 5 forms involving sun-exposed and nonexposed skin with no side effects. Table 1 3 , 4 , 5 summarizes the main features of our patient and the three previously published cases of AEGCG treated with tetracyclines.…”

“…Table 1 3 , 4 , 5 summarizes the main features of our patient and the three previously published cases of AEGCG treated with tetracyclines.…”

Annular elastolytic giant cell granuloma: an unusual presentation in non-sun-exposed areas

“…It has been proposed that factors such as ultraviolet radiation, heat, and vascular damage could generate elastolysis and an antigenic change of the elastic fibers, triggering a cellular immune response and a consequent granulomatous reaction. 1 , 3 AEGCG has been associated with diabetes mellitus, hyperlipidemia, hypertension, vascular occlusion, arthritis and hematological and solid organ malignancies. 4 …”