Actinide-specific sequestering agents and decontamination applications

Raymond, Kenneth N.; Smith, William L.

doi:10.1007/3-540-10407-0_14

Cited by 65 publications

(29 citation statements)

References 97 publications

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“…Similar to high-valent transition metals, tetravalent Pu is strongly hydrolyzed at physiological pH 10 . In the absence of steric constraints, Pu 4+ tends to form complexes that are about as stable as those of trivalent first row transition metals, notably Fe 3+ , because the metals’ charge to radius ratios are similar 1,11 . These properties give plutonium a chemistry that partly resembles transition metals, especially iron.…”

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confidence: 99%

An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium

et al. 2011

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Plutonium is a toxic synthetic element with no natural biological function, but it is strongly retained by humans when ingested. Using small angle X-ray scattering, receptor binding assays, and synchrotron X-ray fluorescence microscopy we find that rat adrenal gland (PC12) cells can acquire plutonium in vitro through the major iron acquisition pathway, receptor-mediated endocytosis of the iron transport protein serum transferrin; however only one form of the plutonium-transferrin complex is active. Low-resolution solution models of plutonium-loaded transferrins derived from small angle scattering demonstrate that only transferrin with plutonium bound in the protein’s C-terminal lobe and iron bound in the N-lobe (PuCFeNTf) adopts the proper conformation for recognition by the transferrin receptor protein. Although the metal binding site in each lobe contains the same donors in the same configuration and both lobes are similar, the differences between transferrin’s two lobes act to restrict, but not eliminate, cellular Pu uptake.

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confidence: 99%

An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium

et al. 2011

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“…PuFfi the fluorescence (at 2300 nm) has a smaller lifetime (0.21 msec); there must be accessible nonradiative decay paths because the flrst excited State of PuFg lies at about 4550 cm"' (2200 nm) [26,27].An entirely different and important achievement in plutonium chemistry has been the development of plutonium-specific sequestering agents[28,29] (Fig. 3).…”

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confidence: 99%

Advances in Chemistry of the Actinide Elements

Morss

1984

Radiochimica Acta

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Recent research accomplishments that elucidate the bonding and reactivity of the actinides are highlighted in this review. Improved syntheses of protactinium and transplutonium metals and Compounds have led to determination of physical properties that reveal effects of 5f interactions. Theimodynamic measurements on metals, aqueous ions, and oxides have yielded more systematic understanding of the chemistry of the entire actinide series. Advances in bonding include the preparation of new organoactinide Compounds with strong a and TT metal-carbon and metal-hydrogen bonds; the development of new actinide complexing, sequestering, and extracting agents; and the study of chemical consequences of radioactive decay on oxides and halides. New techniques that impact actinide chemistry are laser fluorescence and photochemistry, radiocoulometry, and pulse radiolysis. Progress has also been made in outlining the basic chemical behavior of the heaviest actinides and the transactinides.Two isomorphs of ThBr4 are known, the well-known /3-ThBr4 and a low-temperature, poorly-characterized a-ThBr4. Below 92 K, j3-ThBr4 displays Splitting of a Raman Vibration and of a bromine nuclear quadrupole resonance line, and new X-ray and neutron diffraction lines appear [2,7]. These observations are not consistent with any conventional superlattice of the tetragonal unit cell, and are caused by a second-order phase transition in which bromine atoms along the c ciystallographic axis are displaced sinusoidally from their sites with a repeating distance of 3.201 c. This phenomenon is a subject of intense investigation and illustrates how careful measurements on pure, Single ciystals can reveal new scientific ideas.

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“…1978, Raymond and Smith 1981 . The rationale for this view is that, in mammals, Pu(iv) becomes associated with the iron (Fe(III)) transport and storage systems, and that enterobactin forms the most stable Fe(iii) complex known with a formation constant of 10 52 (Harris et al .…”

Section: Introductionmentioning

confidence: 97%

“…1978, Durbin et al . 1980, Raymond and Smith 1981 . The most promising compound was the sodium salt of N 1 ,N5 ,N10 ,N 14 -tetrakis (2,3-dihydroxy-4 carboxybenzoyl)-tetra-azatetradecane, code named 3,4,3-LICAM(C) [LICAM(C)] .…”

Section: Introductionmentioning

confidence: 97%

The Efficacies of Pure LICAM(C) and DTPA on the Retention of Plutonium-238 and Americium-241 in Rats after Their Inhalation as Nitrate and Intravenous Injection as Citrate

Stradling¹,

Stather²,

Gray³

et al. 1989

International Journal of Radiation Biology

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The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.

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Actinide-specific sequestering agents and decontamination applications

Cited by 65 publications

References 97 publications

An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium

An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium

Advances in Chemistry of the Actinide Elements

The Efficacies of Pure LICAM(C) and DTPA on the Retention of Plutonium-238 and Americium-241 in Rats after Their Inhalation as Nitrate and Intravenous Injection as Citrate

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