Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression

Gao, Zhuowei; Deng, Guanghui; Li, Yunjia; Huang, Huacong; Sun, Xuegang; Shi, Hao; Yao, Xiaofen; Gao, Lei; Ju, Yongle; Luo, Min

doi:10.1016/j.biopha.2020.110092

Cited by 79 publications

(50 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Actinidia chinensis Planch. contains two antitumor components, ursolic acid and oleanolic acid, which promote ferroptosis by inhibiting GPX4 and SLC7A11/xCT proteins in GC cells [131]. As an active component of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), tanshinone IIA (Tan IIA) has been found to have an antitumor effect in GC [132,133].…”

Section: Effects Of Dietary Nutrients and Phytochemicals On Ferroptosis And Gastric Diseasesmentioning

confidence: 99%

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Liu

Xiao

2021

IJMS

View full text Add to dashboard Cite

Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.

show abstract

Section: Effects Of Dietary Nutrients and Phytochemicals On Ferroptosis And Gastric Diseasesmentioning

confidence: 99%

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Liu

Xiao

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…erefore, TCM decoction and pill cannot be directly added to in vitro cell culture. Many studies have shown that drug-containing rat serum is often used in vitro experiments [46][47][48]. In addition, the drug-containing rat serum has a good effect in simulated in vitro experiments.…”

Section: Discussionmentioning

confidence: 99%

Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1α/VEGF Signaling Pathway

Tang

Xie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. The incidence of bone fracture and bone-related diseases is increasing every year. Angiogenesis plays a vital role in fracture healing and bone repair. This study assessed the benefits of Taohong Siwu (TSW) decoction on angiogenesis in isolated rat aortic endothelial cells (RAEC) treated with TSW-containing serum. Methods. The components of TSW decoction were analyzed by liquid chromatography-mass spectrometry (LC-MS). TSW-containing serum was prepared by gavage of TSW decoction to Sprague-Dawley (SD) rats. The effects of TSW-containing serum on the viability, migration, wound healing, and angiogenesis of RAEC were detected by the MTT, transwell, wound healing, and Matrigel lumen formation assays, respectively. In addition, the effects of an HIF-1α inhibitor on TSW-containing serum-induced RAEC were also assessed. The effects of TSW-containing serum on the expression of the HIF-1α signaling pathway were evaluated by qRT-PCR and western blot analysis. Results. LC-MS revealed that TSW decoction primarily contained isomaltulose, choline, D-gluconic acid, L-pipecolic acid, hypotaurine, albiflorin, and tryptophan. TSW-containing serum significantly increased the viability, migration, wound healing, and angiogenesis of RAEC in a dose-dependent manner. Furthermore, our results demonstrated that HIF-1α and VEGF expressions were increased in the cells of TSW-containing serum groups, whereas VHL expression was decreased. The effects of TSW-containing serum were reversed by treatment with an HIF-1α inhibitor. Conclusion. These results suggested that TSW decoction enhanced angiogenesis by regulating the VHL/HIF-1α/VEGF signaling pathway.

show abstract

“…One of the main reasons is the lack of su ciently speci c and sensitive biomarkers for early diagnosis (17). It has been shown that ferroptosis is involved in STAD proliferation, migration, resistance and other biological behaviors (18)(19)(20)(21)(22). LncRNAs are pivotal regulators of ferroptosis, playing different biological roles in different cancer type (7)(8)(9)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma

Wang¹,

Sun²,

Wang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Ferroptosis is a form of cell death involved in diverse physiological context. Increasing evidence suggests that there is a closely regulatory relationship between ferroptosis and long noncoding RNAs (lncRNAs).Method: RNA-sequencing data from The Cancer Genome Atlas (TCGA) data resource and ferroptosis-related genes from FerrDb (http://www.zhounan.org/ferrdb/) data resource were employed to select differentially expressed lncRNAs. We performed Univariate Cox regression and multivariate Cox analyses analysis on these differentially expressed lncRNAs to screen independent predictive factors. Subsequently, we established two signatures for predicting overall survival (OS) and progression-free survival (PFS). Finally, experiments were conducted to verify the roles of LASTR in gastric cancer (GC).Results: We identified 12 differentially expressed lncRNAs linked with OS and 13 associated with PFS. Kaplan-Meier(K-M) analyses exhibited that the high-risk group was related to a poor prognosis of stomach adenocarcinoma (STAD). The AUCs of the OS, as well as PFS signatures of lncRNAs were 0.734 and 0.771, respectively, indicating their excellent efficacy in predicting STAD prognosis. Our experimental results illustrated that the inhibition of LASTR inhibited tumor proliferation and migration in GC.Conclusion: This comprehensive evaluation of the ferroptosis-related lncRNA landscape in STAD unearthed novel lncRNAs related to carcinogenesis. In addition, we also experimentally confirmed the effects of LASTR on proliferation, migration and ferroptosis. These results provide potential novel targets for tumor treatment and promote personalized medicine.

show abstract

Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression

Cited by 79 publications

References 44 publications

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1α/VEGF Signaling Pathway

Ferroptosis-Related Long Non-Coding RNAs and the Roles of LASTR in Stomach Adenocarcinoma

Contact Info

Product

Resources

About