Actinobacteria mediated synthesis of bio-conjugate of carbon dot with enhanced biological activity

Chowdhury, Devasish; Majumdar, Sristi; Thakur, Debajit

doi:10.1007/s13204-020-01392-0

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…As already mentioned in the previous section, CDs antibacterial activity strongly correlates with the N content of CDs and surface charges. Thus, many reported antimicrobial CDs use amines or quaternary ammonium salts as starting materials for the synthesis of these carbon-based probes to ensure the formation of CDs with cationic groups on the CD surface [ 51 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Cds As Bacteria Targeting and Antibacterial Agentsmentioning

confidence: 99%

Carbon Dots as an Emergent Class of Antimicrobial Agents

2021

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Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.

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