Actinomyces-associated lesions located in the gingiva: Case report of rare gingival lesions

Acar, Buket; Çağlayan, Feriha; İnkaya, Ahmet Çağkan; Kurtulan, Olcay

doi:10.4103/0976-237x.205067

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…In addition, we performed LEfSE analysis and hierarchical clustering, which showed several taxa highly enriched only in the initial sample or only at day 7 post-inoculum, while some of which were maintained throughout the culture ( Supplementary Figures 8-9 ). Examples are Streptococcus or Veillonella , whose relative abundances were preserved in both groups, suggesting the favorable conditions of the model in supporting the growth of colonizers, while other colonizers, as Actinomyces 44 , did not survive. Enriched taxa on day 7 were identified as Saccharibacteria TM7 45,46 or Neisseria 47 , which are health and host-associated bacteria, although the role of Saccharibacteria TM7 is not fully understood yet.…”

Section: Resultsmentioning

confidence: 98%

Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model

Adelfio,

Callen,

Diaz

et al. 2024

Preprint

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Host-oral microbiome interactions are known to be critical in maintaining local and systemic health of the human body, although they are difficult to study in both clinical and in vitro applications. Despite efforts, recapitulation of gingival architecture and physiological characteristics of the periodontal niche cannot be achieved by traditional tissue engineering strategies. Here, we advanced our humanized three-dimensional gingival model by co-culturing it with a healthy patient-derived microbiomes for seven days within an oral bioreactor that mimics native salivary dynamics. Our results indicated long-term host and microbiome viability, host barrier integrity and physiological response, and preservation of healthy microbial populations and interbacterial dialogues. The model has proven useful in successfully mimicking tissue homeostasis at the interface of the periodontal niche and suitable for the introduction of immune cells. Future studies will focus on using the model as a comparator of periodontal inflammation and identifying biomarkers associated with eubiotic/dysbiotic profiles

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Section: Resultsmentioning

confidence: 98%

Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model

Adelfio,

Callen,

Diaz

et al. 2024

Preprint

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“…This bacterium is one of the three constituents, along with Porphyromonas gingivalis and Treponema denticola , of the so-called ‘red complex’ in severe periodontal infections. Another genus that specifically decreased its relative abundance in the mouthwash-treated group was Actinomyces , which is part of the healthy oral microbiome; however, under a disruption of the environmental balance, mucosal tissue integrity or defense system, it can turn into a pathogen, initiating a prolonged chronic inflammatory process that can lead to the creation of a tumor-like mass, tissue destruction, osteolysis and multiple sinus tracts [ 52 , 53 ]. On the other hand, both Granulicatella and Abiotrophia are pathobionts of the human mouth linked to endocarditis and pulmonary, central nervous system and ocular infections [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

A mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals

Pascual¹,

Otal

Torrent-Silla³

et al. 2023

Journal of Oral Microbiology

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Background Many antimicrobial compounds in mouthwashes can have a negative impact on the oral microbiome. O-cymen-5-ol, a compound derived from a phytochemical, has a targeted mode of action and is being used as an alternative. However, its effect on the native oral microbiome is unknown. Aim To assess the effect of a mouthwash formulated with o-cymen-5-ol and zinc chloride on the oral microbiome of healthy individuals. Methods A mouthwash formulated with o-cymen-5-ol and zinc chloride was administered to a cohort of 51 volunteers for 14 days, while another cohort of 49 volunteers received a placebo. The evolution of the oral microbiome in both groups was analysed using a metataxonomic approach. Results Analysis of the oral microbiome showed that the mouthwash selectively targeted potential oral pathogens while maintaining the integrity of the rest of the microbiome. Specifically, the relative abundance of several potentially pathogenic bacterial taxa, namely Fusobacteriota , Prevotella , Actinomyces , Granulicatella , Abiotrophia , Lautropia , Lachnoanaerobaculum , Eubacterium (nodatum group) and Absconditabacteriales (SR1) decreased, while the growth of Rothia , a nitrate-reducing bacterium beneficial for blood pressure, was stimulated. Conclusions The use of o-cymen-5-ol and zinc chloride as antimicrobial agents in oral mouthwashes is a valuable alternative to classical antimicrobial agents.

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“…Actinomyces spp. usually inhabit oral, gastrointestinal and female genital tract (1,2). The disease commonly manifests as slowly progressive cervicofacial (50% of cases), thoracic and pulmonary (15-20% ) or abdominopelvic (about 20% ) infection (3).…”

Section: Introductionmentioning

confidence: 99%

Splenic actinomycosis in a patient with chronic granulomatous disease: a case report and review of the literature

Ayaz

Hasanli

Demirci-Duarte

et al. 2019

Infect Dis Clin Microbiol

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Actinomycosis is a granulomatous disease caused by filamentous, gram-positive, anaerobic bacteria. Actinomyces spp. are constituents of the normal flora of mucous membranes. These organisms may cause infection after surgery or damage to the mucosal barrier. Main clinical presentations of actinomycosis are cervicofacial, thoracic, and abdominal forms of the disease. Most cases are caused by Actinomyces israelii, whereas cases due to other Actinomyces spp. are occasionally reported. Actinomycosis is often misdiagnosed because it can mimic other pathological conditions. Besides, Actinomyces spp. are difficult to isolate because they require specific growth conditions. Herein we report a case of splenic actinomycosis caused by Actinomyces naeslundii in a 30-year-old woman with chronic granulomatous disease. Abdominal ultrasound imaging revealed hepatic nodules and splenic abscess; the latter was sampled and cultured. After microbiological diagnosis, she received intravenous (IV) penicillin followed by long-term oral amoxicillin-clavulanate. Abscesses regressed with drainage and prolonged antibiotic therapy. The patient was followed-up for six months without any symptoms. Splenic actinomycosis is a rare disease but should be considered in the differential diagnosis of splenic abscesses in patients with chronic granulomatous disease.

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Actinomyces-associated lesions located in the gingiva: Case report of rare gingival lesions

Cited by 6 publications

References 11 publications

Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model

Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model

A mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals

Splenic actinomycosis in a patient with chronic granulomatous disease: a case report and review of the literature

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