Actinomyces israelii and Fusobacterium nucleatum brain abscess in an immunocompetent patient: case report.

Abstract

Introduction . Brain abscess is the most common focal infectious neurological injury. Until the 19th century this condition was fatal, however the development of neuroimaging for early diagnosis, neurosurgery and antibiotic therapy in the 20th century has led to new therapeutic strategies decreasing mortality from 50% in the 1970s to less than 10% nowadays. Case report . A immunocompetent patient without any addiction presented to the emergency department with dysarthria and frontal headache at home. The clinical examination was normal. Further investigations revealed a polymicrobial brain abscess as a consequence of an ear, nose or throat (ENT) infection with locoregional extension with a dental starting point involving Actinomyces israelii and Fusobacterium nucleatum . In spite of a rapid diagnosis and a neurosurgical management associated with an optimal treatment by a dual therapy made of ceftriaxone and metronidazole the patient unfortunately died. Conclusion. This case report shows that despite a low incidence and a good prognosis following the diagnosis, brain abscesses can lead to patient’s death. Thereby, a routine dental examination of patients with neurological signs may be useful to improve the diagnosis made by the clinician. The use of microbiological documentation, the respect of pre-analytical conditions, the interaction between the laboratory and the clinicians are indispensable for an optimal management of these pathologies.

Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review

“…The patients' sole preoperative clinical presentation was limb dysfunction and no other signs of infection were detected through medical history review, blood testing, or CSF examination. Although brain abscess caused by Fusobacterium nucleatum has been reported previously (Lamtri Laarif et al, 2023;Park et al, 2023), this type of cryptogenic brain abscess caused by Fusobacterium nucleatum is certainly rare.…”