Actinomycetes are a natural resource for sustainable pest control and safeguarding agriculture

Diab, Mohamed Khaled; Mead, Hala Mohamed; Ahmad Khedr, Mohamad M.; Abu-Elsaoud, Abdelghafar Mohamed; El-Shatoury, Sahar Ahmed

doi:10.1007/s00203-024-03975-9

Cited by 3 publications

References 182 publications

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Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study

Dai,

Ma,

Dang

et al. 2024

Pest Management Science

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BACKGROUNDPlant pathogenic fungi pose a severe threat to crop yield and food security. This study aims to investigate the potential antifungal activity and mechanism of action of camphor‐thiazole derivatives against six plant pathogenic fungi. A novel series of camphor‐thiazole derivatives were designed, synthesized and evaluated for their antifungal effects against Rhizoctonia solani, Fusarium graminearum, Valsa mali, Alternaria solani, Colletotrichum orbiculare and Botryitis cinerea.RESULTSMost of the synthesized camphor‐thiazole derivatives exhibited notable antifungal activity. Amongst them, compounds C5, C10 and C17 showed significant activity against R. solani with median effective concentrations (EC50) values in the range 3–4 μg mL−1, demonstrating superior antifungal efficacy to the control drug boscalid (EC50 = 1.23 μg mL−1). Structure–activity relationship and density functional theory analysis emphasized the critical role of substituent selection in optimizing the biological activity of these compounds. Moreover, preliminary mechanistic studies revealed that compound C5 induced abnormal mycelial and cellular morphology in R. solani as observed using scanning and transmission electron microscopy, and triggered the production and accumulation of reactive oxygen species. Additionally, the increased concentration of C5 resulted in enhanced cell membrane permeability.CONCLUSIONIn this study, the designed and optimized compound C5 emerged as a promising candidate for potent antifungal agents. The results demonstrate that synthesized camphor‐thiazole derivatives possess potent antifungal activity and can serve as lead compounds for further optimization in antifungal agent development. © 2024 Society of Chemical Industry.

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Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study

Dai,

Ma,

Dang

et al. 2024

Pest Management Science

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Discovery of novel D/L-camphor derivatives containing oxime ester as fungicide candidates: Antifungal activity, structure-activity relationship and preliminary mechanistic study

Dai,

Ma,

Xue

et al. 2024

Advanced Agrochem

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Bioprotection by Natural Sources for Sustainable Agriculture

Baş

2024

New Perspectives on Seed Germination [Working Title]

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Biocontrol, or protection, involves using living organisms such as microbes, insects, and their by-products to safeguard food security against harmful pathogens and pests in agriculture. Excessive use of synthetic inputs such as fertilizers and pesticides in farming can lead to soil accumulation and crust formation over time. Inorganic chemical pollutants enter the food chain through plant absorption from the soil, resulting in environmental and public health concerns. Compensating for the destructive effects of synthetic pesticides on agroecosystems is challenging. Therefore, it is important to discuss the future of plant health and the restoration of microbial communities in the phyllosphere, endosphere, rhizosphere, and plant growth–promoting microorganisms using natural sources. Local governments should enforce legal restrictions on the frequency and quantity of conventional pesticide use, promote the use of bioagents, and encourage farmers and stakeholders to adopt natural alternatives. This chapter introduces various bio-based materials that can serve as natural alternatives to synthetic chemicals for eradicating or minimizing invasive phytopathogen species through biocontrol in plant protection.

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Actinomycetes are a natural resource for sustainable pest control and safeguarding agriculture

Cited by 3 publications

References 182 publications

Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study

Design and synthesis of camphor‐thiazole derivatives as potent antifungal agents: structure–activity relationship and preliminary mechanistic study

Discovery of novel D/L-camphor derivatives containing oxime ester as fungicide candidates: Antifungal activity, structure-activity relationship and preliminary mechanistic study

Bioprotection by Natural Sources for Sustainable Agriculture

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