Actinomycetoma in Arm Disseminated to Lung with Grains of Nocardia brasiliensis with Peripheral Filaments

Muñoz-Hernández, Bertha; Noyola, María Cecilia; Palma-Cortés, Gabriel; Rosete, Dora; Galván, Miguel Ángel; Manjarrez, María Eugenia

doi:10.1007/s11046-009-9189-5

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…While working on this manuscript we conducted an extensive image search looking for histolopathological samples of human pulmonary nocardiosis due to Nocardia brasiliensis to directly compare with our findings but we were unsuccessful, none seem to be documented. However, one report of an invasive N. brasiliensis infection of the skin with pulmonary involvement showed lesions extremely similar to the ones we show in this manuscript [19]. Additionally, granulomas due to other Nocardia spp.…”

Section: Discussionsupporting

confidence: 87%

Experimental Granulomatous Pulmonary Nocardiosis in Balb/c Mice

Lira

Limón-Flores

Salinas-Carmona

et al. 2016

Preprint

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Section: Discussionsupporting

confidence: 87%

Experimental Granulomatous Pulmonary Nocardiosis in Balb/c Mice

Lira

Limón-Flores

Salinas-Carmona

et al. 2016

Preprint

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“…However, one report of an invasive N . brasiliensis infection of the skin with pulmonary involvement showed lesions extremely similar to the ones we show in this manuscript [ 19 ]. Additionally, granulomas due to other N ocardia spp .…”

Section: Discussionsupporting

confidence: 82%

Experimental Granulomatous Pulmonary Nocardiosis in BALB/C Mice

et al. 2016

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Pulmonary nocardiosis is a granulomatous disease with high mortality that affects both immunosuppressed and immunocompetent patients. The mechanisms leading to the establishment and progression of the infection are currently unknown. An animal model to study these mechanisms is sorely needed. We report the first in vivo model of granulomatous pulmonary nocardiosis that closely resembles human pathology. BALB/c mice infected intranasally with two different doses of GFP-expressing Nocardia brasiliensis ATCC700358 (NbGFP), develop weight loss and pulmonary granulomas. Mice infected with 109 CFUs progressed towards death within a week while mice infected with 108 CFUs died after five to six months. Histological examination of the lungs revealed that both the higher and lower doses of NbGFP induced granulomas with NbGFP clearly identifiable at the center of the lesions. Mice exposed to 108 CFUs and subsequently to 109 CFUs were not protected against disease severity but had less granulomas suggesting some degree of protection. Attempts to identify a cellular target for the infection were unsuccessful but we found that bacterial microcolonies in the suspension used to infect mice were responsible for the establishment of the disease. Small microcolonies of NbGFP, incompatible with nocardial doubling times starting from unicellular organisms, were identified in the lung as early as six hours after infection. Mice infected with highly purified unicellular preparations of NbGFP did not develop granulomas despite showing weight loss. Finally, intranasal delivery of nocardial microcolonies was enough for mice to develop granulomas with minimal weight loss. Taken together these results show that Nocardia brasiliensis microcolonies are both necessary and sufficient for the development of granulomatous pulmonary nocardiosis in mice.

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“…(55) When the lung is affected, the aspect is of consolidation with necrosis, and pleural effusion can be seen. (56) Mycetoma generally affects agriculturists and is endemic in Latin America, India and Africa. (20,57) Mycetoma is not a colonization of a preexisting pulmonary cavity; therefore, the use of this term as a synonym for "fungus ball" should be avoided.…”

Section: Mycetoma (Micetoma)mentioning

confidence: 99%

Consenso brasileiro ilustrado sobre a terminologia dos descritores e padrões fundamentais da TC de tórax

et al. 2010

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O objetivo deste novo consenso brasileiro é atualizar e dar continuidade à padronização da terminologia dos principais descritores e padrões fundamentais da TC de tórax em língua portuguesa. Este consenso contém uma descrição sucinta dos principais termos utilizados na TC de tórax e ilustrações de exemplos clássicos. O grupo de autores é formado por médicos radiologistas membros do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, especializados em radiologia torácica, e por pneumologistas membros da Sociedade Brasileira de Pneumologia e Tisiologia, com particular interesse em diagnóstico por imagem.

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Actinomycetoma in Arm Disseminated to Lung with Grains of Nocardia brasiliensis with Peripheral Filaments

Cited by 8 publications

References 12 publications

Experimental Granulomatous Pulmonary Nocardiosis in Balb/c Mice

Experimental Granulomatous Pulmonary Nocardiosis in Balb/c Mice

Experimental Granulomatous Pulmonary Nocardiosis in BALB/C Mice

Consenso brasileiro ilustrado sobre a terminologia dos descritores e padrões fundamentais da TC de tórax

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