Actinomycosis of the larynx

Abstract

Actinomycosis is a rare chronic granulomatous disease that involves the upper airway and gastrointestinal tract. Approximately 40-55% of actinomycosis comprises the cervicofacial form. It presents a challenging clinical diagnostic dilemma because of variable presentations in the head and neck. Herein, we report a rare case of actinomycosis presenting as a vocal cord nodule in a healthy 21-year-old man who was not immunocompromised and had no other known medical disease.

Laryngeal Actinomycosis: A Case Report and Systematic Review of 32 Cases in the Literature

“…Our case and analysis of similar cases shows that primary infection of the larynx restricted only to the glottis or its substructures, has been successfully treated and suppressed with excision of the lesion and eight weeks of oral penicillin based therapy [10,12,13,21]. More involved lesions, such as those with concurrent pulmonary involvement require more invasive therapy, including a course of intravenous antibiotic therapy.…”

“…No cases reported seeding of disease to new site when the primary lesion was restricted only to the larynx. Cases with involvement limited to the larynx were treated with a shorter term dose of oral only antibiotics: 500-625 mg oral penicillin based therapy three times a day for up to 8 weeks following excisional biopsy [10,12,13,21].…”

Combined Modality Treatment for Laryngeal Actinomycosis - A Rare Cause of Hoarseness

“…In literature, laryngeal actinomycosis have been managed traditionally by combined surgical and medical modalities [4][5][6][7]. In this case, surgical debulking followed by antimicrobial treatment was administered.…”

Atypical Osteomyelitis of the Skull Base and Craniovertebral Junction Caused by Actinomyces Infection -Case Report-

“…Actinomyces are gram-positive, anaerobic, filamentous bacteria, causing chronic infection in compromised patients in various systemic lesions. 11,15) The most frequent site is the craniofacial region, whereas involvement of the skull base is quite rare, 14) with only a few cases. 1,12) The delay until the biopsy was very long in the previous cases, and the definitive diagnosis was made after the disease was rather advanced.…”