Actinomycotic osteomyelitis of the mandible: review of 15 cases

Bartkowski, S; Zapała, Jan; Heczko, Piotr B; Szuta, Mariusz

doi:10.1016/s1010-5182(98)80037-1

Cited by 62 publications

(41 citation statements)

References 5 publications

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“…Cervicofacial actinomycosis has a high prevalence for males, affecting adult patients (Bartkowski et al, 1998). However, in rare situations, pediatric population also can be involved, exhibiting also prevalence for male and mandible (Robinson et al), which differs from our report.…”

Section: Discussioncontrasting

confidence: 76%

“…In this report, the treatment performed was according the literature recommendation that is a high and prolonged dose of antibiotics, associated with drainage and surgical intervention (Rubin & Krost;Lerner, 1998;Bartkowski et al) for excision of necrotic tissue and curettage of affected bony tissue (Bennhoff, 1984). This is necessary to remove the necrotic bone, which is an excellent anaerobic growth medium that could impair the antibiotics from penetrating in the lesion and reach the colonies (Rubin & Krost; Goldberg).…”

Section: Discussionmentioning

confidence: 99%

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Maxillary Osteomyelitis by Actinomyces in a Child

Neto

Carvalho²,

Conceição

et al. 2018

Int. J. Odontostomat.

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Actinomycosis is a bacterial infection caused by Actinomyces species, which usually affect the soft tissues of the cervicofacial region of adult males. Clinically, it's characterized by a slow-growing indurated mass, especially in the submandibular area. However, in a few cases, the jaws bones can be affected developing osteomyelitis characteristics. The aim of this paper is to report a rare clinical case of Actinomycotic Osteomyelitis affecting the maxilla of a child, involving the maxillary sinus, orbital and zygomatic areas that was treated by the association of antibiotic therapy and surgical debridement. The patient's 2 years follow-up was uneventful and no signs of the lesion recurrence.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Maxillary Osteomyelitis by Actinomyces in a Child

Neto

Carvalho²,

Conceição

et al. 2018

Int. J. Odontostomat.

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“…• Chronic osteitis, • Osteolytic lesion with granulation tissue which presents as polycystic at X-ray examination [8] • On the tongue (3% of cases), with the formation of a hard nodule attached to the muscular layer [9] • At the pterygomaxillary site with lockjaw • As a parapical or paradental abscess [10,11] • The regional lymph nodes are rarely involved and if so, without pain [12] Histological aspect: The main element is an actinomycotic granuloma, made up of a network of threads and claviform formations, the peripheral tissue is granulomatous and full of plasma-cells, fibroblasts, giant-cells and blood vessels, there is also an infiltrate of polymorphonucleates. An actinomycotic granuloma may develop into a purulent form with several fistulas in the case of multiple granulomas or into a productive form with fibrosis.…”

Section: Symptomsmentioning

confidence: 99%

Cervico-Facial Actinomycosis: Epidemiological and Clinical Comments

Tortorici¹,

Burruano²,

Buzzanca³

et al. 2008

American J. of Infectious Diseases

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Abstract:In a retrospective investigation performed in the department of Surgical Odontostomatology of Palermo University Polyclinic from 1997-2006, the authors examined 12 cases of cervico-facial actinomycosis, taking into consideration age range, gender distribution, predisposing factors and symptoms. In concordance with reports in literature, they found that the disease was perimandibular in 65%, they also report the diagnostic methods and therapeutic approaches used in the study.

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“…The tetracycline employed in this work is Doxycycline Hyclate (Doxy). It has been used to treat a wide variety of infections including periodontitis [18], osteomyelitis [19][20][21] and Methicillin Resistant Staphylococcus Aureus (MRSA) [22]. Beneficial effects on bone metabolism have been reported for Doxy even at low concentrations, i.e.…”

Section: Introductionmentioning

confidence: 99%

Drug delivery from injectable calcium phosphate foams by tailoring the macroporosity–drug interaction

2015

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Please cite this article as: Pastorino, D., Canal, C., Ginebra, M-P., Drug delivery from injectable calcium phosphate foams by tailoring the macroporosity-drug interaction, Acta Biomaterialia (2014), doi: http://dx.doi.org/10. 1016/ j.actbio.2014.10.031 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractIn this work novel injectable Calcium Phosphate Foams (CPFs) were combined with an antibiotic (Doxycycline) to design an innovative dosage form for bone regeneration.The material structure, its drug release profile and antibiotic activity were investigated, while its clinical applicability was assessed through cohesion and injectability tests.Doxycycline had a clear effect on both the micro-and macro-structure of the CPFs due to its role as nucleating agent of hydroxyapatite and a drying effect on the paste. Doxycycline-loaded CPFs presented interconnected macroporosity, which increased drug availability as compared to Calcium Phosphate Cements, and was a critical parameter controlling the release kinetics, which followed a non-Fickian diffusion model. Up to 55% (1 mg) of the drug was released progressively in 5 days, the percentage released being proportional to the macroporosity of the CPFs. All Doxycycline-containing foams had immediate cohesion and were injectable. Moreover, antibacterial activity was observed against Staphylococcus Aureus and Escherichia Coli. Thus, in addition to enhancing osteoconduction and material resorption, macroporosity allows tuning the local delivery of drugs from injectable calcium phosphates.

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Actinomycotic osteomyelitis of the mandible: review of 15 cases

Cited by 62 publications

References 5 publications

Maxillary Osteomyelitis by Actinomyces in a Child

Maxillary Osteomyelitis by Actinomyces in a Child

Cervico-Facial Actinomycosis: Epidemiological and Clinical Comments

Drug delivery from injectable calcium phosphate foams by tailoring the macroporosity–drug interaction

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