Action of Cholecystokinin and Caerulein on the Rabbit Sphincter of Oddi

Abstract

The action of cholecystokinin (CCK) and caerulein upon the rabbit sphincter of Oddi was investigated by eiectromyography, manometry and measuring of the flow. Intravenous injection of CCK resulted in a marked rise of the sphincter activity with a maximum at the 1st min and return to the basal level at the 10th min. Injection of increasing doses of hormone showed that the effect was proportional to the logarithm of the dose. The same results were obtained with caerulein. Parallely, CCK provoked a rise of the biliary pressure also proportional to the logarithm of the dose and a reduction to the biliary flow. The discrepancies between these results and some other experiments are discussed. It is concluded that, in the rabbit, CCK increases the activity of the sphincter of Oddi.

Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder. Mechanisms of action.

“…The effect of CCK on the sphincter of Oddi (SO), however, is controversial. While most studies have shown that CCK relaxes the SO (7)(8)(9), one has demonstrated SO contraction (10). Moreover, the mechanism of action of CCK on the SO has not been conclusively elucidated (11,12).…”

“…NIETHODS 72 adult cats of either sex weighing 2-5 kg wvere studied. The animals were anesthetized with intramuscutlar Ketainiiie hydrochloride (30 mg/kg body wt) and maintained with small doses of [5][6][7][8][9][10][11][12][13][14][15] mg/kg as needed. Thev were studied in the supine position with a constant slow intravenouis infusion of Ringer's solution with 5% dextrose.…”

Proximal and Distal Segments of the Possum Sphincter of Oddi Respond Differently to Neural and Cholecystokinin Octapeptide Stimulation in vitro

“…In the human [32], cat [33, 34]and dog [35], SO relaxation has been observed. Excitatory SO responses have been reported in the guinea pig [36, 37, 38], opossum [39, 40, 41, 42], rabbit [43]and prairie dog [44, 45]. In the possum, variable responses were observed following in vivo application of CCK-8 [46], and may reflect the different responses of the proximal versus the distal BD-SO.…”

Effect of prepyloric gastric transection and anastomosis on sphincter of Oddi cyclic motility in conscious dogs

“…18 Cholecystokinin (CCK) has varying effects on the SO, depending on species. 14,[19][20][21][22] In dogs and humans, CCK normally inhibits SO activity. 21,22 However, the effect of CCK on the SO becomes excitatory after distal gastrectomy in humans.…”