Action of Diphenylhydantoin Sodium on the Adrenal Gland

Staple, P. H.

doi:10.1016/s0140-6736(51)92598-6

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An Historical Perspective1

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1955

1991

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Article7

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Cited by 16 publications

(4 citation statements)

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“…Later in 1951, STAPLE suggested a connection between the pituitary and adrenal glands and PHT-IGH (37). HAIM, in 1955 believed that the connective tissue in PHT-IGH was "immature" (38).…”

Section: An Historical Perspectivementioning

confidence: 99%

On the mechanism of drug‐induced gingival hyperplasia

Brown¹,

Beaver

Bottomley

1991

J Oral Pathology Medicine

107

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Proposed mechanisms of the side effect of drug-induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans, immunoglobulins, gingival fibroblast phenotype population differences, epithelial growth factor, pharmacokinetics and tissuebinding, collagenase activation, disruption of fibroblast cellular sodium/calcium flux, folic acid and a combination hypothesis are evaluated.

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“…Later in 1951, STAPLE suggested a connection between the pituitary and adrenal glands and PHT-IGH (37). HAIM, in 1955 believed that the connective tissue in PHT-IGH was "immature" (38).…”

Section: An Historical Perspectivementioning

confidence: 99%

On the mechanism of drug‐induced gingival hyperplasia

Brown¹,

Beaver

Bottomley

1991

J Oral Pathology Medicine

107

View full text Add to dashboard Cite

show abstract

“…It has been found in experim ental anim als to increase the weight of the adrenals {Woodbury 1952. Staple 1953, Bonnycastle and Bradley 1960 and to cause hypertrophy and hislological changes in the adrenal cortex (Staple 1951(Staple , 1953. It has also been shown to inhibit the corticotrophin (ACTH) release induced by various stim uli in the rat {Bonnycastle and Bradley 1956Bradley , 1960.…”

mentioning

confidence: 99%

Effect of Diphenylhydantoin Treatment on the Release of Corticotrophin in Epileptic Patients

Rinne¹

1966

Stereotact Funct Neurosurg

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“…Recently, Staple 6 found that diphenylhydantoin (Dilantin) produced degenerative lesions in the adrenal cortex of rats. He has Submitted for publication April 5, 1955 suggested that this drug might exert its anticonvulsant effect by decreasing adrenal cortex activity.…”

mentioning

confidence: 99%