Action of foot activator on growth and differentiation of cells in hydra

Hoffmeister, S. A. H.

doi:10.1016/0012-1606(89)90316-3

Cited by 13 publications

(5 citation statements)

References 32 publications

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“…When a consensus CRE motif was used in band-shift assays to measure the CRE-binding activity present in nuclear extracts prepared from regenerating hydra, dramatic modifications of the CRE-binding pattern were observed (68). During regeneration, the increase in CRE-binding can be detected 30 minutes after cutting (B.G., unpublished observation); this increase is observed independently of the polarity of regeneration but is absent in nuclear extract from upper halves of Hydra oligactis, which are deficient for basal regeneration (Fig. 4).…”

Section: Head Activator and Cyclic Amp Pathwaymentioning

confidence: 89%

Signaling molecules in regenerating hydra

Galliot

1997

BioEssays

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Ever since it was discovered in hydra, regeneration has remained a stimulating question for developmental biologists. Cellular approaches have revealed that,within the first few hours of apical or basal hydra regeneration, differentiation and determination of nerve cells are the primary cellular events detectable. The head and foot activators (HA, FA), neuropeptides that are released upon injury, are signaling molecules involved in these processes. In conditions where it induces cellular differentiation or determination, HA behaves as an agonist of the cyclic AMP (cAMP) pathway involving the modulation of CREB nuclear transcription factor activity. This cascade would be required for proper regeneration,regardless of whether the polarity involved is apical or basal. Modulations of the protein kinase C pathway, which have been shown to affect apical or basal positional values, might signal to bring about this polarity; however, endogenous ligands responsible for this modulation are as yet unknown.

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Section: Head Activator and Cyclic Amp Pathwaymentioning

confidence: 89%

Signaling molecules in regenerating hydra

Galliot

1997

BioEssays

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“…For head-specific determination, which may be the most dramatic decision in the cell cycle, a very high HA concentration is required, for terminal differentiation and for cell proliferation lower HA concentrations suffice. Since the foot activator can replace HA in stimulating proliferation [9], we would like to postulate that it is the high HA concentration that is the decisive signal for head specific morphogenesis.…”

Section: Discussionmentioning

confidence: 99%

Effect of head activator on proliferation, head-specific determination and differentiation of epithelial cells in hydra

Schaller¹,

Hofinann²,

Javois

1990

Differentiation

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“…All these activities had been previously ascribed to a foot activator, enriched from hydra tissue [26,27]. Recently, the cDNA coding for pedin was cloned from hydra [28].…”

Section: Pedinmentioning

confidence: 99%

Hydra – ancient model with modern outfit

Hoffmeister-Ullerich

2007

Cell. Mol. Life Sci.

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The control of growth and differentiation is a central question not only for developmental biologists but increasingly for medical research as well. The freshwater polyp hydra was one of the first organisms to be used as a model system for the study of this question. It was chosen because of its simple body plan and because it is made up of only seven to eight different cell types. Recent research has shown that despite their simple body plan, cnidarians already exhibit an impressive repertoire of molecular tools which are responsible for the control of growth and differentiation and amongst which peptides appear to play an important role.

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Action of foot activator on growth and differentiation of cells in hydra

Cited by 13 publications

References 32 publications

Signaling molecules in regenerating hydra

Signaling molecules in regenerating hydra

Effect of head activator on proliferation, head-specific determination and differentiation of epithelial cells in hydra

Hydra – ancient model with modern outfit

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