Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats

Choi, Jeong-Hwa; Rhee, In‐Koo; Park, Keun-Yong; Park, Kun-Young; Kim, Jongki; Rhee, Soon-Jae

doi:10.1016/s0024-3205(03)00433-8

Cited by 60 publications

(29 citation statements)

References 22 publications

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“…These compounds have been reported to be present in various organs of rats, including target organs for Cd, such as kidneys and liver [37]; however, their penetration into the bone tissue has not been investigated, but it cannot be excluded. The available data indicating that consumption of polyphenols improves bone turnover and BMD in both human [21] and experimental animals [16,23] confirm the possibility of the direct impact of these compounds on bone status.…”

Section: Figmentioning

confidence: 70%

“…Owing to the large number of -OH groups, these compounds are capable of chelating metal ions, including Cd 2+ [4,6,14]. It has been revealed that some food products abundant in polyphenolic compounds, including especially green tea and soybeans, may offer protection against various effects of exposure to Cd; however, the data is very sparse and refers only to chosen compounds [3,[5][6][7][8][9][15][16][17].…”

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confidence: 99%

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The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

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!Recently, we demonstrated in a rat model that consumption of a polyphenol-rich extract obtained from the berries of Aronia melanocarpa could protect from cadmium-induced disorders in bone turnover and changes in bone mineral status. The aim of this study was to investigate whether the osteoprotective effect of this extract is mediated by the oxidative defense system. Enzymatic and nonenzymatic antioxidants, total antioxidative and oxidative status, hydrogen peroxide, and markers of oxidative protein, lipid, and DNA damage were determined in bone tissue at the distal femoral epiphysis of female Wistar rats receiving 0.1 % aqueous A. melanocarpa extract (prepared from the lyophilized commercial extract containing 65.74 % of polyphenols) as the only drinking fluid and/or cadmium in the diet (1 and 5 mg/kg) for 3, 10, 17, and 24 months. The total oxidative and antioxidative status of the serum was also evaluated. The administration of A. melanocarpa extract provided significant protection from cadmium-induced oxidative stress in the bone and serum, and from lipid peroxidation and oxidative damage to the protein and DNA in the bone tissue. Numerous correlations were noted between indices of the oxidative/antioxidative bone status and markers of bone metabolism previously assayed in the animals receiving A. melanocarpa extract. The results allow the conclusion that the ability of A. melanocarpa extract to mediate the oxidative defense system and prevent oxidative modifications of protein, lipid, and DNA in the bone tissue plays an important role in its osteoprotective action under exposure to cadmium. The findings provide further evidence supporting our suggestion that chokeberry may be a promising natural agent for protection against the toxic action of cadmium in women chronically exposed to this metal. Abbreviations

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Section: Figmentioning

confidence: 70%

mentioning

confidence: 99%

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

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“…In rats exposed to Cd over 20 weeks (in order to increase bone resorption and thus decrease BMD 31 ), urinary deoxypyridinoline (an index of bone resorption):creatinine ratios were increased in those consuming a catechin-free diet, or a diet containing just 0·25 % catechin. However, in rats fed a diet containing larger doses of catechin (0·5 %), urinary deoxypyridinoline:creatinine ratios were similar to that of the control group.…”

Section: Flavonoidsmentioning

confidence: 99%

Bone mineral density, polyphenols and caffeine: a reassessment

2007

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Several studies have shown beneficial associations between tea consumption and bone mineral density (BMD) and fracture risk. Current investigations into potential mechanisms of benefit are focused upon the F and polyphenol components of tea. However, previous studies have pointed towards caffeine consumption as a potential risk factor for low BMD and high fracture risk. Tea, therefore, represents an interesting paradox as a mildly caffeinated beverage that may enhance bone health. Fruit and vegetable intake has also been associated with BMD, and it is now apparent that several fruit and vegetable components, including polyphenols, may contribute positively to bone health. Evidence surrounding the function(s) of polyphenol-rich foods in bone health is examined, along with more recent studies challenging the relevance of caffeine consumption to in vivo Ca balance. Plant foods rich in polyphenols such as tea, fruit and vegetables, as significant factors in a healthy diet and lifestyle, may have positive roles in bone health, and the negative role of caffeine may have been overestimated. The present review covers evidence of dietary mediation in positive and negative aspects of bone health, in particular the roles of tea, fruit and vegetables, and of caffeine, flavonoids and polyphenols as components of these foods. Since the deleterious effects of caffeine appear to have been overstated, especially in respect of the positive effects of flavonoids, it is concluded that a reassessment of the role of caffeinated beverages may be necessary.

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“…A EGCG vêm sendo considerada responsável pelo efeito protetor do chá verde por apresentar ação antioxidante (Cook e Samman, 1996;Yang et al, 1998;Anghileri e Thouvenot, 2000;Erba et al, 2005;Khan e Mukhtar, 2007;Sanna et al, 2014), antiinflamatória (Nagle et al, 2006;Bahoruna et al, 2010;Heber et al, 2014), antimicrobiana (Ikigai et al, 1993;Stapleton e Taylor, 2002;Blanco et al, 2003;Rocaro et al, 2004;Jeon et al, 2014;Lee e Tan, 2015), anticarcinogênica (Lee et al, 2009;Yang e Wang, 2010;Kang et al, 2010;Rao e Pagidas, 2010;Li et al, 2014;Maruyama et al, 2014;Butt et al, 2015), antiangiogênica (Tudoran et al, 2012;Heber et al, 2014;Koh et al, 2014), mineralizadora (Hegarty et al, 2000;Vestergaard et al, 2001;Choi et al, 2003), anti-hipertensiva (Basu e Lucas, 2007), antitumoral (Lee et al, 2009;Yang e Wang, 2010;Kang et al, 2010;Rao e Pagidas, 2010;Lemarie et al, 2013;Khan et al, 2014) e reparadora tecidual .…”

Section: Introductionunclassified

“…Estudos epidemiológicos revelam que a EGCG também pode trazer benefícios para os tecidos mineralizados, aumentando a densidade mineral óssea (Hegarty et al, 2000;Vestergaard et al, 2001;Choi et al, 2003) e reduzindo os riscos de osteoporose ou fratura (Kanis et al, 2000). Diversos estudos realizados in vitro e in vivo revelam que os benefícios ao tecido ósseo são decorrentes da ação da EGCG na inibição da osteoclastogênese (Lin et al, 2008;Lee et al, 2010;Oka et al, 2012) ou na indução da morte celular de osteoclastos por apoptose (Yun et al, 2007).…”

Section: Introductionunclassified

Formulação à base de Epigalocatequina-3-galato, derivada do chá verde, desenvolvida para uso endodôntico: estudo físico-químico e biológico

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Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats

Cited by 60 publications

References 22 publications

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

Bone mineral density, polyphenols and caffeine: a reassessment

Formulação à base de Epigalocatequina-3-galato, derivada do chá verde, desenvolvida para uso endodôntico: estudo físico-químico e biológico

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