Action of Halothane on Myocardial Adenylate Cyclase of Rat and Cat

Gangat, Y.; Vulliemoz, Yvonne; Verosky, Mariagnes; Danilo, Peter; Bernstein, Keith J.; Triner, L.

doi:10.3181/00379727-160-40409

Cited by 9 publications

(3 citation statements)

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“…The effects of halothane on cAMP formation have been reported by several authors using a variety of experimental paradigms. These vary from measurements of whole tissue contents after anaesthesia [31,46,66] to examining the effects on agonistdriven responses [2,4,23,54] (table V). What is clear, and in accord with previous sections, is that no consistent effects have been observed.…”

Section: Interaction Of Anaesthetic Agents With Signal Transductionmentioning

confidence: 99%

“…In neuronal tissues, halothane increases cAMP concentrations in vivo [31,46], decreases noradrenaline stimulated cAMP formation [54] or is ineffective [2]. In cardiac tissue, a general decrease is observed [23,66], whilst in the liver, halothane increases both basal and glucagon stimulated cAMP formation [4]. These experiments are attempting to mimic (or to examine directly) what would happen in vivo.…”

Section: Interaction Of Anaesthetic Agents With Signal Transductionmentioning

confidence: 99%

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Signal Transduction: G Proteins and Second Messengers

Lambert

1993

British Journal of Anaesthesia

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The mechanisms underlying receptor-effector coupling are fundamental to our understanding of cellular function. A central issue in this area is how cell surface receptors transduce and amplify incoming signals. Other articles in this issue of the Journal cover the details of Ca 2+ channel structure and their interactions with anaesthetic agents. This review concentrates on two of the most well characterized second messenger systems, adenylyl cyclase-cAMP and inositol polyphosphate-[Ca 2+ ][.

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Section: Interaction Of Anaesthetic Agents With Signal Transductionmentioning

confidence: 99%

Section: Interaction Of Anaesthetic Agents With Signal Transductionmentioning

confidence: 99%

Signal Transduction: G Proteins and Second Messengers

Lambert

1993

British Journal of Anaesthesia

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“…Adenylate cyclase activity was measured in whole-tissue homogenates by the method of Krishna et al [14], as described previously [10]. Each assay contained 500-840 pg protein, and the reac tion was carried out for 5 min at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Developmental Changes in Adenylate Cyclase Activity in Canine Myocardium

Vulliemoz¹,

Verosky²,

Rosen³

et al. 1984

Dev Pharmacol Ther

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Basal and epinephrine-induced adenylate cyclase activity in homogenates of dog myocardium increased significantly from birth to adulthood, without further change with advancing age. The stimulatory effect of epinephrine (i.e. the net increase over basal activity), however, increased (p < 0.05) during the first week after birth only and then remained constant. While fluoride-stimulated activity increased, 5'-guanylyl imidodiphos- phate [Gpp(NH)p]-stimulated activity declined gradually during development (p < 0.05). In the presence of Gpp(NH)p and epinephrine at concentrations producing a maximal effect, the enzyme activities in all dogs, except in the 1-day-old, were not significantly different and were comparable to that of fluoride-stimulated activity in adult dogs. The results suggest that age-related alterations in the characteristics of the guanine nucleotide regulatory protein may account, at least in part, for the changes in adenylate cyclase activity occurring during development.

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Volatile Anesthetics and Second Messengers in Cardiac Tissue

Vulliemoz

1991

Advances in Experimental Medicine and Biology

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Action of Halothane on Myocardial Adenylate Cyclase of Rat and Cat

Cited by 9 publications

References 0 publications

Signal Transduction: G Proteins and Second Messengers

Signal Transduction: G Proteins and Second Messengers

Developmental Changes in Adenylate Cyclase Activity in Canine Myocardium

Volatile Anesthetics and Second Messengers in Cardiac Tissue

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