Action of interleukin-3 on the proliferation of leukaemic progenitor cells from patients with acute myeloblastic leukaemia

Asano, Yoshizo; Shibata, Shoichiro; Kobayashi, Shinji; Okamura, Seiichi; Akazawa, Kouhei; Niho, Yoshiyuki

doi:10.1046/j.1365-2257.1998.00132.x

Clinical &Amp; Laboratory Haematology

1998

DOI: 10.1046/j.1365-2257.1998.00132.x

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Action of interleukin-3 on the proliferation of leukaemic progenitor cells from patients with acute myeloblastic leukaemia

Yoshizo Asano

Shoichiro Shibata

Shinji Kobayashi

et al.

Abstract: In the present study, we examined the effects of interleukin-3 (IL-3) on the proliferation of leukaemic progenitor cells from 11 Japanese patients with acute myeloblastic leukaemia (AML), including the effect of its combination with granulocyte/macrophage colony-stimulating factor (GM-CSF) or granulocyte colony-stimulating factor (G-CSF). The results showed that IL-3 sufficiently stimulated the proliferation of AML progenitor cells in almost all the cases examined, and that the stimulation pattern of IL-3 was … Show more

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Cited by 3 publications

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References 16 publications

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“…Both IL-4 and IL-10 inhibit leukemia cell secretion of IL-lp, TNFa, and GM-CSF, and increase leukemia cell release of IL-lra in virro (1,(12)(13)(14)(15)(16)(17)(18)(19). The two cytokines were initially described as growth factors for lymphocytes.…”

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confidence: 99%

In VivoEffects of IL-4, IL-10, and Amifostine on Cytokine Production in Patients with Acute Myelogenous Leukemia

Tao

Nayini

et al. 2001

Leukemia & Lymphoma

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Both IL-4 and IL-10 have been shown in vitro to inhibit leukemia cell secretion of IL-1beta, GM-CSF, and TNFalpha, and increase leukemia cell release of IL-1ra. In this study, we have investigated the in vivo effects of IL-4, IL-10, and amifostine on cytokine production in patients with acute myelogenous leukemia (AML). Serum IL-1ra, IL-1beta, TNFalpha, GM-CSF, and SCF levels were measured in AML patients who received IL-4, IL-10, or amifostine. No significant changes in the serum levels of IL-1ra, IL-1beta, TNFalpha, GM-CSF, and SCF were found in AML patients who received amifostine. Both IL-4 and IL-10 were found to increase serum IL-1ra. This data is in accord with the in vitro studies. However, IL-4 increased serum GM-CSF levels and IL-10 increased serum IL-1beta and TNFalpha levels. These in vivo effects of the two cytokines differ from their in vitro effects. Despite the similar effects of IL-4 and IL-10 on cytokine production by AML cells in vitro, different effects were observed in AML patients in vivo. IL-4 increased serum SCF levels, whereas IL-10 decreased serum SCF levels. IL-4 increased serum GM-CSF levels, whereas IL-10 had no effect on them. Although IL-10 increased serum IL-1beta and TNFalpha levels, IL-4 had no effect on them. These findings indicate that the in vitro effects of IL-4 and IL-10 do not necessarily reflect their in vivo effects, and that the complex effects of the two cytokines on serum cytokine levels make it difficult to predict their therapeutic potential.

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mentioning

confidence: 99%

In VivoEffects of IL-4, IL-10, and Amifostine on Cytokine Production in Patients with Acute Myelogenous Leukemia

Tao

Nayini

et al. 2001

Leukemia & Lymphoma

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Implication of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Interleukin-3 (IL-3) in Children with Acute Myeloid Leukaemia (AML)

Elbaz

Shaltout

2000

Hematology

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Granulocyte-macrophage colony stimulating factor (GM-CSF) and Interleukin-3 (IL-3) are increasingly used to stimulate granulopoiesis in neutropenic patients but these are rarely used in the lights of knowledge of the endogenous CSF-levels. In this study we measured serum levels of GM-CSF and IL-3 at diagnosis and after remission in children with acute leukaemia, using an enzyme linked immuno-sorbent assay (ELISA) techniques in 14 patients with acute myeloid leukaemia (AML) and 27 patients with acute lymphoblastic leukaemia (ALL). Twelve healthy age-matched children were used as a reference group. AML patients showed a highly significant increase in serum levels of GM-CSF and IL-3 before induction of therapy (p < 0.0001) compared to the reference control group, with a highly significant decline of both GM-CSF and IL-3 (p < 0.0001) after successful remission. On the other hand, ALL patients showed no significant elevation of GM-CSF and IL-3 at diagnosis (p > 0.5), with no significant difference between preinduction and postinduction serum levels of either (p > 0.5). Since these cytokines are known to be fundamental for the growth of AML cells, we postulate that the pretreatment levels of both GM-CSF and IL-3 could play a role in the pathogenesis of AML.

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G-CSF does not Stimulate Leukemic Stem Cells in Vivo.

Asano

Numata

Takase

et al. 2003

J Clin Exp Hematopathol

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The effect of G-CSF on leukemic stem cells, which can support the long-term proliferation of leukemic cells in vivo, needs to be clarified to confirm the long-term safety of clinical use of G-CSF. When we examined the effect of G-CSF on leukemic stem cells in NOD/SLID mice using a transplantation assay, the engraftment of leukemic cells derived from 8 AML cases was neither supported by G-CSF alone, nor enhanced by G-CSF plus GM-CSF, IL-3 and SCF. These findings suggest that G-CSF was not able to stimulate leukemic stem cells into maintaining the long-term proliferation of leukemic cells in vivo.

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Action of interleukin-3 on the proliferation of leukaemic progenitor cells from patients with acute myeloblastic leukaemia

Cited by 3 publications

References 16 publications

In VivoEffects of IL-4, IL-10, and Amifostine on Cytokine Production in Patients with Acute Myelogenous Leukemia

In VivoEffects of IL-4, IL-10, and Amifostine on Cytokine Production in Patients with Acute Myelogenous Leukemia

Implication of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Interleukin-3 (IL-3) in Children with Acute Myeloid Leukaemia (AML)

G-CSF does not Stimulate Leukemic Stem Cells in Vivo.

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