Action of Lysine-Vasopressin on Human Electroencephalographic Activity

Timsit‐Berthier, M.; Mantanus, H.; Devos, J; Spiegel, René

doi:10.1159/000117906

Cited by 31 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Icv AVP increased wakefulness in rats (128). Intranasal AVP prompted increases in stage 2 sleep and decreases in SWS and REMS in controls (129). After infusion of the peptide to normal human subjects REMS decreased (130).…”

Section: Arginine Vasopressinmentioning

confidence: 95%

Sleep and endocrine regulation

Steiger¹

2003

Front Biosci

View full text Add to dashboard Cite

A bidirectional interaction exists between sleep electroencephalogram (EEG) and endocrine activity in various species including humans. Various hormones (peptides, steroids) were shown to participate in sleep regulation. A keyrole was shown for the reciprocal interaction between sleep-promoting growth hormone-releasing hormone (GHRH) and sleep-impairing corticotropin-releasing hormone (CRH). Changes in the GHRH:CRH ratio result in changes of sleep-endocrine activity. There is good evidence that the change of this ratio in favor of CRH contributes to aberrances of sleep during aging and depression. Besides of GHRH ghrelin and galanin promote SWS, whereas somatostatin is another sleep-impairing factor. NPY acts as a CRH antagonist and induces sleep onset. Prolactin enhances rapid eve-movement sleep (REMS) in rats. SWS is enhanced in patients with prolactinoma. Other studies on the influence of prolactin of human sleep are lacking. There is a controversy whether CRH promotes REMS. In humans vasocactive intestinal polypeptide (VIP) appears to play a role in the temporal organization of sleep, since after VIP administration the NREMS-REMS cycle decelerated. Several neuroactive steroids (pregnenolone, progesterone, allopregnanolone, dehydroepiandrosterone) exert specific effects on sleep EEG via GABAA receptors. Cortisol appears to enhance REMS. Finally gonadal hormones participate in sleep regulation. Estrogen replacement therapy and CRH-1 receptor antagonism in depression are beneficial clinical applications of the basic research presented here.

show abstract

Section: Arginine Vasopressinmentioning

confidence: 95%

Sleep and endocrine regulation

Steiger¹

2003

Front Biosci

View full text Add to dashboard Cite

show abstract

“…Therefore, acute changes in attention after ACTH 4–10 in principle cannot be used to predict the effects of a subchronic administration of the substance. Even effects opposite in direction are possible after acute versus subchronic treatment with neuropeptides [15, 16]. Here, the effects of an acute and subchronic intranasal treatment with ACTH 4–10 on attention were compared.…”

Section: Introductionmentioning

confidence: 99%

Brain Potentials and Attention after Acute and Subchronic Intranasal Administration of ACTH 4–10 and Desacetyl-α-MSH in Humans

et al. 1999

View full text Add to dashboard Cite

Neuropeptides related to adrenocorticotropin (ACTH) are potent regulators of neurobehavioral functions. In humans, ACTH and its behaviorally active fragment ACTH 4–10 have been consistently found to diminish event-related brain potential (ERP) signs of focussing attention. This study aimed at (1) evaluating effects of ACTH 4–10 on ERP indicators of attention in healthy controls after intranasal administration of the peptide. This route of administration has been proposed to provide a more direct access to the brain than the intravenous administration of the peptide, (2) comparing acute effects and effects of a subchronic treatment with ACTH 4–10, and (3) comparing effects of ACTH 4–10 with those of desacetyl-α-MSH (corresponding to ACTH 1–13 amide) which like ACTH 4–10 binds to subgroups of the melanocortin receptor family. Double-blind placebo-controlled experiments were completed in 54 healthy young subjects. ERPs were recorded while the subject performed an auditory selective attention task. Moreover, a modified Stroop interference test including motivational (food, sex) and nonmotivational words was performed. Acute intranasal administration of ACTH 4–10 (1 mg) reduced the processing negativity (PN) of the ERP over frontal and central cortical areas (p < 0.05) indicating diminished focussing of attention. Moreover, on this condition subjects were more prone to interference on the Stroop task especially with motivational words (p < 0.05). Subchronic administration of ACTH 4–10 (1 mg/day over 6 weeks) did not affect PN and Stroop performance. Acute intranasal administration of desacetyl-α-MSH at equimolar doses (1.68 mg) also remained ineffective. However, some measures of Stroop performance appeared to improve after subchronic desacetyl-α-MSH treatment. Results confirm an acute decrease in focussing of attention after ACTH 4–10. These effects of intranasal administration are likely to reflect a direct action of the peptide on respective brain functions. Moreover, they were specific to ACTH 4–10 and were not obtained after equimolar doses of desacetyl-α-MSH, thus excluding a mediation via the known melanocortin receptors.

show abstract

“…Another line of indirect evidence for a vasopressinergic role in attentional selectivity is provided by the findings that link the peptide to CNS activation: (a) The “electrophysiological profile” of humans treated with vasopressin resembles that produced by CNS stimulants such as amphetamine, caffeine, and adrenocorticotropin (ACTH; see Timset-Berthier, Mantanus, Devos, & Spiegel, 1982); (b) treatment with vasopressinlike peptides has been found to reduce reaction time (Durso et al, 1982; Fehm-Wolfsdorf et al, 1984); and (c) vasopressin activates the body's orchestrated response to stress, both by directly augmenting the release of ACTH from the anterior pituitary and by acting synergistically with corticotropin releasing hormone (CRH) in this action (Gillies, Linton, & Lowry, 1982; Mormede, Le Moal & Dantzer, 1985). Various treatments that increase an animal's level of arousal have been found to exert significant, and surprisingly uniform, effects on cue utilization.…”

mentioning

confidence: 99%