Action of Salicylates and Related Drugs on Inflammation

Ungar, Georges; Damgaard, Evelyn; Hummel, Fred P.

doi:10.1152/ajplegacy.1952.171.3.545

Cited by 42 publications

(12 citation statements)

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“…Wounds Treated With Sodium Salicylate.--This drug was used because it has been demonstrated to be an inhibitor of both pepsin (18) and fibrinolysin (19), two very different kinds of proteases. Furthermore, Ungar has shown that in guinea pig liver slices and skin slices sodium salicylate inhibits the proteolysis caused by anaphylactic and anaphylactoid agents (12) and by burning (11).…”

Section: Group I1 Wounds Treated With Sodium Sal@ylate or With Soybementioning

confidence: 99%

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Polymorphonuclear Invasion of Wounded Corneas

Weimar

1957

The Journal of Experimental Medicine

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Polymorphonuclear invasion of the wounded rat cornea is quantitatively described. The inflammatory cells enter the wounded tissue during the 5th postoperative hour. They steadily increase in number until they reach a maximum between 24 and 36 hours and return to normal by about the 6th day. Six hour wounds are used to evaluate the influence of topically applied drugs on the polymorphonuclear infiltration of the wounded area. Sodium salicylate is an effective inhibitor of polymorphonuclear invasion when it is used during the 2nd postoperative hour, but it is without effect when it is applied after this time. Soybean trypsin inhibitor prevents the invasion of polymorphonuclear cells when it is administered during the 2nd hour only, or the 3rd and 4th hours together, or the 5th and 6th hours together. The results indicate that activation of a proteolytic enzyme (or enzymes) in the injured corneal tissue is an essential step leading to polymorphonuclear invasion. During the first 2 postoperative hours the anti-inflammatory effects of both drugs are nearly identical and may reflect an inhibition of the same proteolytic reaction or some different but closely related reactions.

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Section: Group I1 Wounds Treated With Sodium Sal@ylate or With Soybementioning

confidence: 99%

“…Both soybean trypsin inhibitor and sodium salicylate suppress fibrinolysin (15,19), both prevent the proteolysis in tissue slices produced by burning …”

Section: B Wounds Treated With Soybean Trypsinmentioning

confidence: 99%

Polymorphonuclear Invasion of Wounded Corneas

Weimar

1957

The Journal of Experimental Medicine

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“…Among the compounds tested were sodium salicylate which was found to inhibit fibrinolysin in vitro (12), a crystalline protein isolated from soybean by Kunitz r (13) and which 7 General Biochemicals, Inc., Chagrin Falls, Ohio.…”

Section: P R O T E O L Y S I S a N D H I S T A M I N E R E L Ementioning

confidence: 99%

Tissue Reactions to Anaphylactic and Anaphylactoid Stimuli; Proteolysis and Release of Histamine and Heparin

Ungar

Damgaard

1955

The Journal of Experimental Medicine

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Addition of the specific antigen to slices of liver or lung taken from sensitized guinea pigs, or the addition of anaphylactoid agents (tween 20, octadecylamine, morphine, and 48/80) to tissue slices from normal animals, or the perfusion of lung with these agents, has been shown to cause protein breakdown and liberation of histamine and heparin. The dose correlation between these phenomena raises the question of which is the causal event. Suppression of histamine and heparin release by inhibition of proteolysis suggests that the latter is the more fundamental reaction, but the problem probably can not be decided on the basis of present knowledge. Tissue proteolysis induced by the agents investigated in this work results from the action of a protease present in normal tissues as an inactive precursor. Conversion of the proenzyme requires the intervention of a kinase. The tissue kinase seems to be different from the serum kinase which has been shown to be related to complement. Serum kinase, however, also acts on tissue proenzyme and probably plays an important role in tissue reactions as elicited in the intact animal.

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“…M en o n [11] initiated an in vestigation on the in vivo role of soluble aspirin in fibrinolysis and found that aspirin enhanced the euglobulin lysis time in six volunteers after the ad ministration of 1,200 mg of soluble aspirin 24 h prior to the testing. It has been reported, however, that in vitro, anti-inflammatory substances either inhibit fibrinolysis [4,13], which may play an important role in the devel opment of inflammation, or under specific conditions enhance fibrinolytic activity [3,14], The present investigation, therefore, was undertaken in order to further study and elucidate the in vitro effect of aspirin in the blood fibrinolytic mechanism.…”

Section: Introductionmentioning

confidence: 99%

<i>In vitro </i>Effects of Aspirin in Fibrinolysis

Iatridis¹,

Iatridis²,

Markidou³

et al. 1974

Pathophysiol Haemos Thromb

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In in vitro studies, aspirin inhibited the lytic activity of streptokinase (SK), urokinase (UK), plasmin, and of euglobulins prepared from normal and Hageman deficient human plasmas. Aspirin also inhibited the generation of activator activity in the plasminoplastin generation test assay. This anti-fibrinolytic effect of aspirin was not due to its acid pH. Chicken plasma being deficient in Hageman factor and in proactivator exerted also a very potent anti-SK and anti-UK effect.

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Action of Salicylates and Related Drugs on Inflammation

Cited by 42 publications

References 0 publications

Polymorphonuclear Invasion of Wounded Corneas

Polymorphonuclear Invasion of Wounded Corneas

Tissue Reactions to Anaphylactic and Anaphylactoid Stimuli; Proteolysis and Release of Histamine and Heparin

<i>In vitro </i>Effects of Aspirin in Fibrinolysis

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