Action of the stable prostacyclin analogue iloprost on microvascular tone and -permeability in the hamster cheek pouch

Müller, B.; Schmidtke, M.; Witt, Werner

doi:10.1016/0262-1746(87)90008-4

Cited by 48 publications

(21 citation statements)

References 21 publications

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“…Several studies have suggested that PGI 2 preferentially protects vessels in the microcirculation. In a hamster cheek pouch model, for example, iloprost given intravenously during early lipopolysaccharide-induced sepsis prevented cessation of spontaneous arteriolar vasomotion, ameliorated the decrease in arteriolar blood flow, and increased the diameters of arterioles, venules and perfused capillary density [28,29].…”

Section: Resultsmentioning

confidence: 99%

Opening the microcirculation: can vasodilators be useful in sepsis?

2002

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Prostacyclin and nitric oxide donors are the best studied vasodilating agents in experimental sepsis and have shown improved tissue perfusion and oxygen extraction. In several clinical studies prostacyclin has also been shown to have such beneficial effects. Recent studies using orthogonal polarization spectral imaging have shown microcirculatory recruitment by nitric oxide donors in hemodynamically resuscitated septic patients. Whether such therapeutic modalities aimed at recruitment of the microcirculation improve outcome, however, still has to be determined.

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Section: Resultsmentioning

confidence: 99%

Opening the microcirculation: can vasodilators be useful in sepsis?

2002

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“…Experimental evidence suggests that, independent of its direct vasodilator properties, PGEl might have additional effects on vascular smooth muscle. Intraarterial infusion or superfusion of the hamster cheek pouch with PGE, was found to induce a significant increase in arteriolar and venular diameters [44]. In addition, in the hamster cheek pouch microcirculation, topically applied PGEi has been shown to antagonize the vasoconstrictor effects of leukotriene (LT) D4, which can be synthesized by vascular tissue of several species [45,46] including man [47].…”

Section: Eflects On Vascular Smooth Musclementioning

confidence: 99%

Prostaglandin E₁ and arterial occlusive disease: pharmacological considerations

Simmet

Peskar

1988

Eur J Clin Investigation

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“…Iloprost is a stable prostacycline analogue (5). Prostacyclines are primarily synthesized by the endothelium and have potent vasodilator effects.…”

Section: Discussionmentioning

confidence: 99%

“…Its efficacy has been proven in peripheral occlusive diseases and it became a choice for medical treatment in patients who are not amenable to surgery. As has been demonstrated by different studies, iloprost has a vasodilating effect both at the arteriole and at the venule level; thus increasing the distal blood flow by 30% (5). Iloprost is a strong vasodilator thereby reduces peripheral vascular resistance to a significant degree (6).…”

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confidence: 94%