Action of Vitamin C Against Acetaminophen-Induced Hepatorenal Toxicity in Rats

El-Ridi, M.R.; Rahmy, Tarek R.

doi:10.1081/txr-100102324

Cited by 11 publications

(10 citation statements)

References 44 publications

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“…The decrease in serum total GSH levels with the vitamins and their combinations may be due to their ability to neutralize the ROS and, as a result, preventing them from depleting GSH stores. It has been previously reported that high doses of VC are capable of normalizing GSH levels in rats injected with toxic doses of APAP, 43 , 44 and that is in line with our results. As discussed in the case of SOD earlier, the observed elevation of GSH might also be attributed to a compensatory defense mechanism against stress induced by APAP overdose.…”

Section: Discussionsupporting

confidence: 94%

Antioxidative stress effects of vitamins C, E, and B<sub>12</sub>, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Abdulkhaleq¹,

Alhussainy²,

Badr³

et al. 2018

DDDT

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BackgroundSeveral vitamins, including C, E, and B12, have been recognized as antioxidants and have shown hepatoprotective effects against the hepatotoxicity caused by acetaminophen (APAP) overdose. The current investigation aims to study the effect of these vitamins and their combination in protecting the liver from APAP hepatotoxicity in rats.Materials and methodsAn in vitro model of freshly isolated rat hepatocytes was utilized for assessing hepatocyte mitochondrial activity conducted by cell proliferation assay (MTT). The isolated hepatocytes were treated with vitamin C, vitamin E, vitamin B12 and their combination, with and without further addition of toxic concentrations of APAP. In addition, an in vivo experiment was carried out on Sprague Dawley rats treated intraperitoneally for 8 days with emulsions of the vitamins or their combination prior to injecting them with APAP.ResultsIn vitro results showed that vitamins C and B and the combination preparation significantly increased the percentage of hepatocyte mitochondrial activity, both with and without the addition of APAP (P<0.01). The mitochondrial activity in the isolated cultured hepatocytes was further enhanced with APAP addition. In vivo, the vitamins and their combination effectively reduced APAP-induced serum liver enzymes levels, namely ALT, AST, and ALP, and also attenuated oxidative stress and lipids peroxidation confirmed by the results of glutathione, superoxide dismutase, and maloondialdehyde.ConclusionPretreatment with vitamins C, E, B12, or their combination was found to be beneficial in preventing in vivo hepatic oxidative stress induced by APAP overdose. Vitamin C on its own showed superior protection against APAP-induced liver injury in rats compared to the other vitamins. The proliferation of APAP-intoxicated liver cells in vitro was highest when protected with the vitamins’ combination.

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Section: Discussionsupporting

confidence: 94%

Antioxidative stress effects of vitamins C, E, and B<sub>12</sub>, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Abdulkhaleq¹,

Alhussainy²,

Badr³

et al. 2018

DDDT

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“…3), thus the hypersensitivity of the liver to AAP is caused by an AsA deficiency and not an AKR1A- catalyzed detoxification reaction. These protective effects of AsA against AAP hepatotoxicity are consistent with findings reported for rats [31].…”

Section: Discussionsupporting

confidence: 93%

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Kurahashi

Lee

Nabeshima

et al. 2016

Archives of Biochemistry and Biophysics

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“…[6–8] The flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health. The antioxidant capacity of these molecules seems to be responsible for many of their beneficial effects and confers a therapeutic potential in diseases such as cardiovascular diseases, gastric or duodenal ulcers, cancer and hepatic pathologies.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, there are numerous reports indicating that PCM-mediated oxidative stress or hepatotoxicity is attenuated by use of naturally occurring antioxidants and/or free radical scavengers such as vitamins, medicinal plants and flavonoids. [ 6 – 8 ] The flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health. The antioxidant capacity of these molecules seems to be responsible for many of their beneficial effects and confers a therapeutic potential in diseases such as cardiovascular diseases, gastric or duodenal ulcers, cancer and hepatic pathologies.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative potential of quercetin against paracetamol-induced oxidative stress in mice blood

Singh¹,

Singh²,

Kumar³

et al. 2011

Toxicol Int

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The aim of the present study was to evaluate the ameliorative potential of quercetin (QC) against paracetamol (PCM)-induced oxidative stress and biochemical alterations in mice blood. A total of 36 mice were randomly allocated into six groups, six mice in each. Group I served as healthy controls, while groups II and III were administered with N-acetylcysteine (NAC) and QC alone respectively. Group IV was administered with PCM alone. Groups V and VI were administered with PCM on day 0 followed by NAC and QC, respectively, for 6 consecutive days. On day 7th blood samples were obtained and subjected for the assays of oxidative stress and serum biochemical panels. Erythrocytic lipid peroxides contents of alone PCM-intoxicated mice were significantly higher, while reduced glutathione contents were found to be significantly lower in comparison with the healthy controls. The activities of antioxidant enzymes were also found to be singnificantly lower in these mice. Additionally, significantly increased activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase, as well as levels of bilirubin, urea and creatinine were revealed by these mice. Postadministration with QC remarkably alleviated the over production of MDA and improved GSH levels in PCM-intoxicated mice blood. In addition, antioxidant enzymes; glutathione peroxidase, glutathione-S-transferase, superoxide dismutase and catalase activities were also improved significantly in these mice. QC had also considerably ameliorated the altered biochemical parameters toward normalcy. Thus, it can be concluded that QC may constitute a remedy against PCM-induced oxidative stress and reno-hepatic injuries.

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Action of Vitamin C Against Acetaminophen-Induced Hepatorenal Toxicity in Rats

Cited by 11 publications

References 44 publications

Antioxidative stress effects of vitamins C, E, and B<sub>12</sub>, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Antioxidative stress effects of vitamins C, E, and B<sub>12</sub>, and their combination can protect the liver against acetaminophen-induced hepatotoxicity in rats

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Ameliorative potential of quercetin against paracetamol-induced oxidative stress in mice blood

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