Action potential conduction block of nerves in vitro by potassium citrate, potassium tartrate and potassium oxalate

Peacock, J.M.; Orchardson, R.

doi:10.1034/j.1600-051x.1999.260106.x

Cited by 28 publications

(10 citation statements)

References 11 publications

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“…A study by Manochehr-Pour et al [69] was also excluded due to incomplete data reported in the study. The two animal studies by Peacock and Orchardson [74, 75] were also excluded and a pilot study reported by Reinhart et al [80] was excluded. The studies by Sharma [83], Sharma et al [84], and Wara-aswapati et al [94] were also excluded as no data was available at the 6-to-8-week time intervals.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Strontium and Potassium Toothpastes in Treating Dentine Hypersensitivity: A Systematic Review

Karim

Gillam

2013

International Journal of Dentistry

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Objectives. The aim of the present paper was to review the published literature in order to identify all relevant studies for inclusion and to determine whether there was any evidence of the efficacy of strontium and potassium toothpastes in the treatment of dentine hypersensitivity (DH). Methods. Following a review of 94 relevant papers both from searching electronic databases (PUBMED) and hand searching of relevant written journals, 13 studies were identified, and 7 papers (1 for strontium-based toothpastes and 6 for potassium-based toothpastes) were finally accepted for inclusion. The main outcome measures were the methodology and assessment used by Investigators in studies designed to evaluate DH. Results. The results of the present paper would indicate that the reported efficacy of both strontium- and potassium-based toothpastes in relieving DH is questionable. Conclusions. The results from the present paper would appear to support the conclusions of previous investigators that there is only minimal evidence for the efficacy of both strontium- and potassium-based toothpastes in relieving symptoms of DH.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Strontium and Potassium Toothpastes in Treating Dentine Hypersensitivity: A Systematic Review

Karim

Gillam

2013

International Journal of Dentistry

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“…Recent computer modelling studies show a clear role for potassium dynamics in HFS-induced conduction block during electrical stimulation (Bellinger et al 2008a;Liu et al 2008). Also, elevated potassium concentrations in the bath within the ranges observed during stimulus-induced conduction block, are sufficient to depress action potential amplitude and can affect axonal signalling (Hablitz & Lundervold 1981;Kocsis et al 1983;Poolos et al 1987;Peacock & Orchardson 1999;Meeks & Mennerick 2004;Shin et al 2007). Of particular note, potassium concentrations required for complete conduction block are generally higher than those recorded using potassium sensitive electrodes.…”

Section: Role Of Potassium Diffusion In Axon Bundlesmentioning

confidence: 99%

Potassium diffusive coupling in neural networks

Durand

Park

Jensen

2010

Phil. Trans. R. Soc. B

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Conventional neural networks are characterized by many neurons coupled together through synapses. The activity, synchronization, plasticity and excitability of the network are then controlled by its synaptic connectivity. Neurons are surrounded by an extracellular space whereby fluctuations in specific ionic concentration can modulate neuronal excitability. Extracellular concentrations of potassium ([K þ ] o ) can generate neuronal hyperexcitability. Yet, after many years of research, it is still unknown whether an elevation of potassium is the cause or the result of the generation, propagation and synchronization of epileptiform activity. An elevation of potassium in neural tissue can be characterized by dispersion (global elevation of potassium) and lateral diffusion (local spatial gradients). Both experimental and computational studies have shown that lateral diffusion is involved in the generation and the propagation of neural activity in diffusively coupled networks. Therefore, diffusion-based coupling by potassium can play an important role in neural networks and it is reviewed in four sections. Section 2 shows that potassium diffusion is responsible for the synchronization of activity across a mechanical cut in the tissue. A computer model of diffusive coupling shows that potassium diffusion can mediate communication between cells and generate abnormal and/or periodic activity in small ( §3) and in large networks of cells ( §4). Finally, in §5, a study of the role of extracellular potassium in the propagation of axonal signals shows that elevated potassium concentration can block the propagation of neural activity in axonal pathways. Taken together, these results indicate that potassium accumulation and diffusion can interfere with normal activity and generate abnormal activity in neural networks.

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“…As potassium ions diffuse into the dentin tubules and reach the nerve endings, they may disrupt the normal potassium ion concentration gradient across the nerve cell membrane, prevent the re-polarisation of the nerve fibres and thus interrupt the transmission of sensory impulses. 16 A recent study showed that filtering 500 mmol/ L potassium chloride across the dentin under 150 mmHg hydrostatic pressure might temporarily decrease the pain response to air blasts and probing. 17 However, there is no evidence that potassium ions delivered through dentifrices could diffuse into dentin tubules in sufficient amount to affect the extracellular ion concentrations.…”

mentioning

confidence: 99%

Effects of dentin tubule occlusion by dentifrice containing a PVM/MA bioadhesive copolymer in a silica base

Liu

Barnes

DeVizio

et al. 2011

Journal of Dentistry

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Action potential conduction block of nerves in vitro by potassium citrate, potassium tartrate and potassium oxalate

Abstract: Potassium citrate and potassium tartrate were more effective than other potassium salts in blocking nerve conduction and may be more effective dentinal desensitising agents.

Cited by 28 publications

References 11 publications

The Efficacy of Strontium and Potassium Toothpastes in Treating Dentine Hypersensitivity: A Systematic Review

The Efficacy of Strontium and Potassium Toothpastes in Treating Dentine Hypersensitivity: A Systematic Review

Potassium diffusive coupling in neural networks

Effects of dentin tubule occlusion by dentifrice containing a PVM/MA bioadhesive copolymer in a silica base

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