Actions of centrally administered neuropeptide Y on EEG activity in different rat strains and in different phases of their circadian cycle

Zini, Isabella; Pich, Emilio Merlo; Fuxe, K.; Lenzi, P; Agnati, Luigi F.; Härfstrand, Anders; Mutt, Viktor; Tatemoto, K.; Moscara, M.

doi:10.1111/j.1748-1716.1984.tb07483.x

Cited by 52 publications

(28 citation statements)

References 7 publications

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“…In contrast, previous studies found that intracerebroventricular injection of NPY induced the slowing of highfrequency theta activity simultaneously with the speeding up of low-frequency theta waves in cortex, hippocampus, and amygdala in rats (11). Two studies from the same research group found increased synchronized and mixed EEG activity after central administration of NPY in rats (12,49). The differences between the results of the studies above and ours may be because of the different experimental conditions.…”

Section: Discussioncontrasting

confidence: 42%

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Central administration of neuropeptide Y induces wakefulness in rats

Szentirmai

Krueger

2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Neuropeptide Y (NPY) is a well-characterized neuromodulator in the central nervous system, primarily implicated in the regulation of feeding. NPY, orexins, and ghrelin form a hypothalamic food intake regulatory circuit. Orexin and ghrelin are also implicated in sleep-wake regulation. In the present experiments, we studied the sleep-modulating effects of central administration of NPY in rats. Rats received intracerebroventricular injection of physiological saline or three different doses of NPY (0.4, 2, and 10 g in a volume of 4 l) at light onset. Another group of rats received bilateral microinjection of saline or 2 g NPY in the lateral hypothalamus in a volume of 0.2 l. Sleepwake activity and motor activity were recorded for 23 h. Food intake after the control and treatment injections was also measured on separate days. Intracerebroventricular and lateral hypothalamic administration of NPY suppressed non-rapid-eye-movement sleep and rapid-eye-movement sleep in rats during the first hour after the injection and also induced changes in electroencephalogram delta power spectra. NPY stimulated food intake in the first hour after both routes of administration. Data are consistent with the hypothesis that NPY has a role in the integration of feeding, metabolism, and sleep regulation. food intake; lateral hypothalamus; electroencephalogram; fast-Fourier transformation; slow-wave activity NEUROPEPTIDE Y (NPY) is widely distributed in high concentrations in the central nervous system and acts as a neurohormone and neuromodulator. The main source of NPY in the brain is the hypothalamus, particularly the arcuate nucleus (ARC), dorsomedial nucleus (DMN), paraventricular nucleus (PVN), suprachiasmatic nucleus (SCN), and the brain stem (2). NPY is implicated in the regulation of several physiological processes, such as food intake (24, 38), hormone secretions (13, 23, 42), circadian rhythms (1), thermoregulation (19), and blood pressure (7).NPY is part of the widely studied hypothalamic food intake regulatory circuit that also involves orexin, ghrelin, agoutirelated peptide, and melanin-concentrating hormone. All of these neuropeptides stimulate food intake when injected in the cerebral ventricle or in various hypothalamic nuclei (9, 20, 34 -36, 46). The NPY receptor family includes at least six subtypes from which the Y1 and Y5 are implicated in the regulation of food intake. Both receptors are present in the PVN, ARC, medial preoptic area, SCN, supraoptic nucleus, and in the lateral hypothalamus (LH; see Ref. 44). The NPY Y1 receptor may be involved in mediating behavioral effects other than feeding, since mice lacking NPY Y1 receptor show reduced locomotor activity (33).NPY-immunoreactive neurons, originating from the ARC, innervate orexinergic cells in the LH (16). Orexin-immunoreactive axon terminals from the LH end on NPYergic neurons in the ARC (16,28). Ghrelin is known to act through NPYergic pathways in the ARC (22, 37) to stimulate feeding. Orexin is known to play an important role in maintaining wakefulness (36)....

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Section: Discussioncontrasting

confidence: 42%

“…In one study, visual inspection of the electroencephalograms (EEG) suggested that NPY induces a reduction in desynchronized EEG activity and an increase in synchronized and mixed activity in rats (49). Ehlers at al.…”

mentioning

confidence: 99%

Central administration of neuropeptide Y induces wakefulness in rats

Szentirmai

Krueger

2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Central NPY in rodents results in enhanced sleep continuity and electroencephalographic synchronization, 109,110 probably linked with reduced NE and 5-HT (5-hydroxytryptamine) release in the locus coeruleus and dorsal raphe, respectively. NPY-containing neurons in the basal forebrain (BF) are slow-wave sleep-active cells.…”

Section: Hyperarousalmentioning

confidence: 99%

Neuropeptide Y and posttraumatic stress disorder

2012

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“…In mammals, a variety of central functions have been proposed for NPY (Albers and Ferris, 1984;Zini et al, 1984). Biological effects include stimulation of food intake (Clark et al, 1984;Leibowitz, 1984, 1985;, modulation of various cardiovascular and respiratory parameters (Fuxe et al, 1983;Hä rfstrand et al, 1984;Hä rfstrand, 1986), and stimulation of insulin secretion (Moltz and McDonald, 1985;Kuenzel, 1988).…”

mentioning

confidence: 98%