Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease

Abstract

Development and fate of the stem cell are regulated by extrinsic signals from the environment. Endocrine-disrupting chemicals which perturb hormonal signaling in utero and during early childhood may cause deregulation of multiple developmental processes, ranging from breakdown of stem cell niche architecture, developmental reprograming and altered stem cell fate to impaired organ and gonad development and sexual differentiation. Therefore, study of the environmental effects on stem cell integrity and normal development is a new and emerging focus for developmental biologists and cell toxicologists. When combined with new human and mouse stem cell-based models, stem cell differentiation dynamics can be studied in more biologically relevant ways. In this study, we review the current status of our understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis.

Effects of bisphenol compounds on the growth and epithelial mesenchymal transition of MCF-7 CV human breast cancer cells

“…Generally, EDCs bind to hormone receptors such as the androgen receptor (AR) and estrogen receptor (ER) and thereby interrupt the functions of endogenous steroid hormones [ 3 ] . They can threaten health by generating reproductive and developmental disorders and cancer development and progression [ 4 ] . In spite of many widely known hazardous effects of EDCs, eliminating them completely in everyday life is almost impossible because they are applied to various industrial products frequently used such as plastics, pesticides, food packages, cosmetics, and detergents [ 5 ] .…”

Ecotoxic pharmaceuticals, personal care products, and other emerging contaminants: A review of environmental, receptor-mediated, developmental, and epigenetic toxicity with discussion of proposed toxicity to humans

“…Biologically disruptive and toxic chemicals may function as such environmental signals (Kopras et al 2014). Routes of exposure are specific to organism habitats and can include contaminated water, food, and through the atmosphere (Calafat et al 2008;Liao and Kannan 2012 (Kopras et al 2014).…”

Electrochemical sensing of estradiol benzoate using hydroxyapatite with three-dimensional channel frameworks

“…have gained global attention because of their well-known serious adverse effects. 1,2 As an important EDC, estrogens share the characteristics of EDCs, such as they may interact with the endocrine system of organisms and cause non-negligible adverse effects on the reproduction of wildlife and humans. [3][4][5] One such example of an EDC is 17b-estradiol-3benzoate (E2B) which is a ubiquitous environmental agent.…”