1990
DOI: 10.1016/0014-2999(90)90664-r
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Actions of forskolin and isoprenaline on the separated myometrial layers of the guinea-pig uterus: influence of ovarian steroids and pregnancy

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1993
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(2 citation statements)
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“…In previous studies from this laboratory we have demonstrated that there are differences in the responsiveness of the circular and longitudinal myometrial layers of the guinea- pig uterus to sympathomimetic amines. These differences are particularly evident in pregnant and post-partum animals, and in animals treated with ovarian steroids (Hartley et al, 1983a;Adam et al, 1984Adam et al, , 1985Hall & Pennefather, 1990). We have now demonstrated an underlying heterogeneity in the a,-adrenoceptor populations present in the two uterine layers of the dioestrous guinea-pig.…”
Section: Discussionmentioning
confidence: 64%
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“…In previous studies from this laboratory we have demonstrated that there are differences in the responsiveness of the circular and longitudinal myometrial layers of the guinea- pig uterus to sympathomimetic amines. These differences are particularly evident in pregnant and post-partum animals, and in animals treated with ovarian steroids (Hartley et al, 1983a;Adam et al, 1984Adam et al, , 1985Hall & Pennefather, 1990). We have now demonstrated an underlying heterogeneity in the a,-adrenoceptor populations present in the two uterine layers of the dioestrous guinea-pig.…”
Section: Discussionmentioning
confidence: 64%
“…The numbers of P,-adrenoceptors present in the circular and longitudinal layers of the dioestrous guinea-pig uterus are similar (Handberg et al, 1988); however, these receptors are more efficiently coupled to effectors in the longitudinal than in the circular myometrial layer (Hartley et al, 1983a, b;Hall & Pennefather, 1990). We therefore included the P,-adrenoceptor antagonist ICI 118, 551 (Bilski et al, 1983) in the bathing medium in all our experiments.…”
Section: Discussionmentioning
confidence: 99%