The IGF System 1999
DOI: 10.1007/978-1-59259-712-3_23
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Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models

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Cited by 9 publications
(8 citation statements)
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“…Using a transgene driven by the metallothionein-I and other promoters, mice overexpressing IGF-I in multiple tissues display elevated serum IGF-I levels and increased body mass without a significant increase in linear growth [74][75][76]. The increase in weight is due to tissue hypertrophy in many organs, including brain, heart, muscle, and intestine [34][35][36][37].…”
Section: Insulin Stimulates Its Own Secretion and Islet B-cell Growthmentioning
confidence: 98%
“…Using a transgene driven by the metallothionein-I and other promoters, mice overexpressing IGF-I in multiple tissues display elevated serum IGF-I levels and increased body mass without a significant increase in linear growth [74][75][76]. The increase in weight is due to tissue hypertrophy in many organs, including brain, heart, muscle, and intestine [34][35][36][37].…”
Section: Insulin Stimulates Its Own Secretion and Islet B-cell Growthmentioning
confidence: 98%
“…For example, in IGF‐1 KO mice, birth mass and adult body size are reduced to 60% and 30%, respectively, compared to littermate controls (Baker et al , 1993; Romero et al , 2010). Local or global overexpression of IGF‐1 in transgenic mice can increase the rate of skeletal muscle proliferation and differentiation, as well as the growth of brain, connective, and adipose tissue (D’Ercole, 1999; Stratikopoulos et al , 2008).…”
Section: Relationships Between Igf‐1 and Life‐history Traits In mentioning
confidence: 99%
“…Insulin‐like growth factor‐I (IGF‐I) has been shown to promote the growth and development of the central nervous system (CNS) (for reviews, see Feldman et al ., 1997; D'Ercole & Roberts, 1999; Anderson et al ., 2002). IGF‐I can influence the proliferation (Ye et al.…”
Section: Introductionmentioning
confidence: 99%