Actions of Melatonin in the Reduction of Oxidative Stress

Reíter, Russel J.; Tan, Dun‐Xian; Osuna, Carmen; Gitto, Eloisa

doi:10.1159/000025480

Cited by 314 publications

(426 citation statements)

References 88 publications

(133 reference statements)

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“…(17); stabilize sleep-wake cycles (18). Melatonin stimulates several antioxidative enzymes (19) and acts on bone metabolism (20). The hormone exerts its effects both through activation of its receptors (21), through the circulating levels of the hormone or in a more autocrine/paracrine fashion near target tissues (22,23).…”

Section: Melatonin and Its Functionmentioning

confidence: 99%

The role of melatonin in diabetes: therapeutic implications

Sharma

Singh

Ahmad

et al. 2015

Arch. Endocrinol. Metab.

110

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Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 pathway, which mobilizes Ca 2+ from organelles and, consequently increases insulin secretion. Both in vivo and in vitro, insulin secretion by the pancreatic islets in a circadian manner, is due to the melatonin action on the melatonin receptors inducing a phase shift in the cells. Melatonin may be involved in the genesis of diabetes as a reduction in melatonin levels and a functional interrelationship between melatonin and insulin was observed in diabetic patients. Evidences from experimental studies proved that melatonin induces production of insulin growth factor and promotes insulin receptor tyrosine phosphorylation. The disturbance of internal circadian system induces glucose intolerance and insulin resistance, which could be restored by melatonin supplementation. Therefore, the presence of melatonin receptors on human pancreatic islets may have an impact on pharmacotherapy of type 2 diabetes. Arch Endocrinol Metab.2015;59(5):391-9

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Section: Melatonin and Its Functionmentioning

confidence: 99%

The role of melatonin in diabetes: therapeutic implications

Sharma

Singh

Ahmad

et al. 2015

Arch. Endocrinol. Metab.

110

View full text Add to dashboard Cite

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“…The mechanisms of diabetes-related apoptosis are unclear. However, current studies have indicated that diabetes-mediated oxidative stres can induce apoptosis (Allan et al, 1992;Reiter et al, 2000).…”

Section: Introductionmentioning

confidence: 98%

Effects of experimental diabetes on testis proliferations and apoptosis in rats

AKTAS¹,

KANTER²,

ERBOĞA³

et al. 2011

jecm

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This work aimed to investigate the role of diabetes on cell proliferation, and apoptosis in testis. The rats were randomly allotted into one of two experimental groups: control and diabetic group; each group contain 10 animals. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). Testicular damage was examined by using hematoxylin and eosin, immunohistochemical staining of proliferating cell nuclear antigen (PCNA), and apoptosis was determined by terminal-deoxynucleotidyl-transferase mediated dUTP nick end labeling (TUNEL). Potential disorders associated with seminiferous tubular sperm formation were evaluated using the Johnsen score. The mean seminiferous tubule diameter (MSTD) and mean testicular biopsy score (MTBS) values were significantly decreased in diabetic group was compared to the control group. Our data indicate a significant reduction in the expression of PCNA and an enhancement in the activity of TUNEL in testis tissues of the diabetic group. The effects of diabetes on spermatogenesis can be clearly detected as a testicular cell death and decrease in MTBS, MSTD, and PCNA expression.

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“…Several studies have reported that acute aMT administration, an antioxidant and free radical scavenger (Antolin et al, 1996;Tan et al, 2000aTan et al, , 2000bTan et al, , 2002Turjanski et al, 2001), counteracted mitochondrial deficiencies in SAM mice (Okatani et al, 2001(Okatani et al, , 2002a(Okatani et al, , 2002b. The indoleamine and several of its metabolites are scavengers of free radicals and it is now considered a component of the endogenous antioxidant system (Reiter, 1998(Reiter, , 2000Tan et a., 2007).…”

mentioning

confidence: 99%