Actions of multiple doses of resveratrol on oxidative and inflammatory markers in plasma and brain of healthy and arthritic rats

Abstract

Chronic and systemic inflammation affecting the synovial membranes, articular cartilages and bones is the most evident symptom of rheumatoid arthritis. 1 The intense hyperplasia of the articular cartilage takes place with participation of T cells, B cells, macrophages, fibroblasts and pro-inflammatory cytokines, particularly interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFα). 2 Reactive oxygen species, however, also play an important role because the overproduction of pro-inflammatory cytokines stimulates neutrophils and activated macrophages to secrete various kinds of reactive substances in the synovial fluid. 3,4 Furthermore, cytokines released into the synovium also reach the systemic circulation and act in other tissues. Consequently, oxidative stress biomarkers are increased in

Resveratrol ameliorates neuronal apoptosis and cognitive impairment by activating the SIRT1/RhoA pathway in rats after anesthesia with sevoflurane

“…RES has been shown to have a broad range of neuroprotective effects in mammals; for example, Huang et al reported that RES could attenuate β-amyloid-induced neurotoxicity by suppressing inducible nitric oxide synthase production in adult rats [ 24 ]. Castro et al showed that RES also plays an important role in anti-oxidation and anti-inflammation in plasma and brain tissues [ 28 ]. Qian et al suggested that RES reduced brain edema and neuronal apoptosis in a subarachnoid hemorrhage rat model [ 29 ].…”

Therapeutic Effects of Intranasal Administration of Resveratrol on the Rat Model of Brain Ischemia

“…The sham group underwent surgical stress without MCAO or administration of any medication. After MCAO, in the vehicle control and resveratrol groups, vehicle (0.05 percent dimethyl sulfoxide (DMSO) in phosphate-buffered saline, Sigma-Aldrich, St. Louis, MO, USA) or 100 μl of a 135 mg/ml (13.5 mg/rat) resveratrol solution (∼50 mg/kg body weight, Sigma-Aldrich, St. Louis, MO, USA) [ 26 ] in 0.05 percent DMSO were inoculated through drip with a micropipette into each nostril of the rat for intranasal administration once a day for 7 consecutive days, while the rat was in the head-back supine position with a 70°–90° tilt to enhance drug absorption from the nasal cavity and facilitate uptake into the brain, while minimizing drainage into the esophagus and trachea ( Fig. 1 ) [ 27 ].…”