“…In the cow, the focus of the current investigation, these molecules include IGF1 (Bonilla et al, 2011;Sirisathien et al, 2003), CSF2 (Loureiro et al, 2009), the WNT inhibitor DKK1 (Denicol et al, 2014), activin A (Kannampuzha-Francis et al, 2017) and IL6 (Wooldridge et al, 2019). Among the embryo functions regulated by embryokines are promotion of development to the blastocyst stage (Bonilla et al, 2011;Kannampuzha-Francis et al, 2017), protection from cell stress (Jousan & Hansen, 2007), and control of lineage commitment towards inner cell mass and trophectoderm (Denicol et al, 2014;Sang et al, 2020;Wooldridge et al, 2019). Some embryokines, such as CSF2 (Kannampuzha-Francis et al, 2015) and DKK1 (Tríbulo et al, 2017), have been reported to program development in a way that affects postnatal phenotype.…”