Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast <i>in vivo</i> bioimaging

Liao, Zaiyi; Yan, Chenxu; Zhang, Yutao; Ma, Dun; Huang, Jialiang; Zhao, Zijun; Tao, Yining; Liu, Caiqi; Li, Juan; Zhu, Weihong; Guo, Zhiqian

doi:10.1039/d3cc01742g

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…60,61 Among them, aza-BODIPY fluorescent dyes, a kind of newer fluorescent molecule, have been developed in the last decade, which are often used to construct fluorescent dyes in the near-infrared (NIR) region because of their long fluorescence emission wavelengths. 62 Sun and Kim et al synthesized a Pt(II) embedded supramolecular triangle, named SCC10 (Fig. 3A).…”

Section: Bodipy Scaffoldmentioning

confidence: 99%

Recent advances in combatting bacterial infections via well-designed metallacycles/metallacages

Li,

Ye,

Zhao

et al. 2024

Dalton Trans.

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Section: Bodipy Scaffoldmentioning

confidence: 99%

Recent advances in combatting bacterial infections via well-designed metallacycles/metallacages

Li,

Ye,

Zhao

et al. 2024

Dalton Trans.

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“…Liu 30 and Guo31 have already demonstrated the effectiveness of this strategy in modulating the fluorescence properties of BODIPY in the second NIR window (1000− 1700 nm). Their research, which involved hybridizing h i b i t e d .…”

mentioning

confidence: 99%

“…Inspired by these elegant examples, we anticipate that by combining BODIPY with xanthene or other dyes, we can efficiently fine-tune the NIR absorption wavelength of BODIPY dyes, thereby creating innovative PA imaging agents. Notably, pioneering works by Zhao, Liu and Guo have already demonstrated the effectiveness of this strategy in modulating the fluorescence properties of BODIPY in the second NIR window (1000–1700 nm). Their research, which involved hybridizing BODIPY with cyanine or xanthene, led to the development of a series of probe molecules exhibiting excellent NIR emission properties, facilitating the in vivo detection of species, such as hydrogen sulfide.…”

mentioning

confidence: 99%

Near-Infrared Absorbing BODIPY-Xanthene Hybrids for Multiplexed Photoacoustic Imaging

Xu,

Sun,

Wang

et al. 2024

Org. Lett.

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We report a series of ethenylene-bridged D−π−A BODIPY-xanthene hybrid dyes with precisely regulated absorption bands ranging from the far-red to the near-infrared region (NIR, 700−1000 nm) through rational molecular design. These dyes have excellent photoacoustic properties, and their biocompatibility can be significantly improved by facilely introducing water-soluble groups. In vivo two-channel multiplexed photoacoustic imaging demonstrated their high-resolution imaging capabilities, making them promising candidates for future NIR bioimaging applications.

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Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Hu,

Fang,

Zhu

et al. 2024

Adv Funct Materials

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Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among the NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), has emerged as a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure and optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, and remarkable chemical stability, has undergone comprehensive investigation and extensive exploration within the realm of biological theranostics. This work aims to provide a comprehensive summary of the advancements in the development and design strategies of NIR‐II BODIPY fluorophores tailored for advanced biological phototheranostics. Initially, the work elucidates several representative and controllable strategies, concluding the electron‐programming strategy, extension of the conjugated backbone, J‐aggregation strategy, and strategic establishment of activatable fluorophores, which enhance the NIR‐II fluorescence of BODIPY skeletons. Subsequently, developments in NIR‐II fluorescent BODIPY‐based nanoplatforms for biological applications are intricately elaborated. In conclusion, this work outlines future efforts and directions for refining NIR‐II BODIPY to meet evolving clinical demands. It is anticipated that this contribution may provide a feasible reference for the strategic design of organic NIR‐II fluorophores, thereby advancing their potential in future clinical practices.

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Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging

Abstract: Herein, we design a novel "crossbreeding" dye (BC-OH) within the second near-infrared (NIR-II) window based on BODIPY and Chromene chromophores. BC-OH can serve as a platform to construct activatable NIR-II...

Cited by 7 publications

References 29 publications

Recent advances in combatting bacterial infections via well-designed metallacycles/metallacages

Recent advances in combatting bacterial infections via well-designed metallacycles/metallacages

Near-Infrared Absorbing BODIPY-Xanthene Hybrids for Multiplexed Photoacoustic Imaging

Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

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