Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods

Mei, Zihan; Gao, Duyang; Hu, Dehong; Zhou, Honghang; Ma, Teng; Huang, Liang; Liu, Xin; Zheng, Rongqin; Zheng, Hairong; Zhao, Ping; Zhou, Jinhua

doi:10.1016/j.biomaterials.2020.120092

Cited by 84 publications

(61 citation statements)

References 53 publications

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“…Furthermore, in the view of the potential imaging capabilities of this conjugated polymer, [44] it also holds great promise for in vivo imaging and diagnosis of infectious disease. [45] Finally, we recognize that the current colorimetric change is relatively subtle for low concentrations of bacteria (Figure 2c; Figure S2, Supporting Information). Further molecular engineering can be carried out to improve the sensitivity, such as tuning the lowest unoccupied molecular orbital and the highest occupied molecular orbital of the conjugated polymers.…”

Section: Discussionmentioning

confidence: 88%

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Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation

Zhu

You

et al. 2020

Adv Funct Materials

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The electrochromism of a water-soluble naturally oxidized electrochromic polymer, ox-PPE, is harnessed for rapid and facile bacterial detection, discrimination, and susceptibility testing. The ox-PPE solution shows distinct colorimetric and spectroscopic changes within 30 min when mixed with live bacteria. For the underlying mechanism, it is found that ox-PPE responds to the reducing species (e.g., cysteine and glutathione) released by metabolically active bacteria. This reduction reaction is ubiquitous among various bacterial strains, with a noticeable difference that enables discrimination of Gram-negative and Gram-positive bacterial strains. Combining ox-PPE with antibiotics, methicillin-susceptible and methicillinresistant Staphylococcus aureus can be differentiated within 2.5 h. Proofof-concept demonstration of ox-PPE for antimicrobial susceptibility testing is carried out by incubating Escherichia coli with various antibiotics. The obtained minimum inhibition concentrations are consistent with the conventional culture-based methods, but with the procedure time significantly shortened to 3 h.

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Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation

Zhu

You

et al. 2020

Adv Funct Materials

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“…Meanwhile, the acidic tumor microenvironment further promoted the enhancement of the NIR-II PA signal. Such a smart 'specific activation and enhancement' chromogenic nanotheranostics allowed the in vitro Reproduced, with permission, from [61]. (E) Photograph (left) and PAI (right, within the broken circle) of the gar gel phantom embedded with different concentrations of charge-transfer nanocomplex at different depths with stacked chicken breast muscle.…”

Section: Irreversible Reaction-basedmentioning

confidence: 99%

“…More recently, studies have expanded on other analytes that triggered the NIR-II PA effect of the nanoparticles. Mei and colleagues developed a ferricyanide-responsive miniature Au/Ag core-shell nanorods (NRs) for NIR-II PTT and PA imaging of multidrug-resistant Staphylococcus aureus (MRSA) infection (Figure 5D) [61].…”

Section: Irreversible Reaction-basedmentioning

confidence: 99%

“…(D) Schematic illustration of free Ag + released from Au/Ag nanorods (NRs) and the activatable PA performance and photothermal of Au/Ag NRs. Reproduced, with permission, from[61]. (E) Photograph (left) and PAI (right, within the broken circle) of the gar gel phantom embedded with different concentrations of charge-transfer nanocomplex at different depths with stacked chicken breast muscle.…”

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confidence: 99%

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Development of Second Near-Infrared Photoacoustic Imaging Agents

Zhang¹,

Ning²,

Zeng³

et al. 2021

Trends in Chemistry

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Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

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158

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Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H 2 O 2 ) into the lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H 2 O 2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.

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Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods

Cited by 84 publications

References 53 publications

Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation

Polymer Electrochromism Driven by Metabolic Activity Facilitates Rapid and Facile Bacterial Detection and Susceptibility Evaluation

Development of Second Near-Infrared Photoacoustic Imaging Agents

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

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