Activatable Probes Based on Distance‐Dependent Luminescence Associated with Cerenkov Radiation

Kotagiri, Nalinikanth; Niedzwiedzki, Dariusz M.; Ohara, Kohtaro; Achilefu, Samuel

doi:10.1002/ange.201302564

Cited by 15 publications

(14 citation statements)

References 26 publications

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“…These data are in accordance not only with studies on phantoms, but also with spectrofluorimetric studies. This study using organic fluorophores is an important proof-of-concept highly relevant to biological studies because tissues are opaque in the blue region of the spectrum where the CR maximum emission peak lies (note that it echoes previous studies with inorganic nanoparticles, such as quantum dots, albeit not involving FRET)15161718212223. In the near infrared window, the benefit of such a CRET-(FRET) n /NIR strategy is obvious because it led to a radiance boost compared with the weak radiance of CR in that window.…”

Section: In Vivo Studies On the Optical Imagersupporting

confidence: 60%

“…Hence, it appeared that an appropriate strategy might consist in transferring a portion of CR towards the near-infrared window by Cherenkov Radiation Energy Transfer (CRET). We, and others have demonstrated the feasibility of using CR to activate various platforms such as quantum dots and other nanoparticles, lanthanides, and fluorophores14151617181920212223. We rationalized the concept on organic fluorophores and showed that a single population of fluorophore, such as fluorescein, rhodamine-101 or rhodamine-6G, undergoes fluorescence emission upon irradiation by CR (from 90 Y, 177 Lu, or 18 F)(Fig.…”

mentioning

confidence: 98%

“…Such a phenomenon, so-called the Vavilov-Cherenkov effect, is not only function of the energy of the emitted particle, but it also relies on the refractive index of the medium. CR is an optical radiation that quickly became of interest for medical imaging: Cherenkov Luminescence Imaging (CLI) is now used in preclinical4567891011121314151617181920212223 and clinical24252627 settings. Some radiopharmaceuticals used in nuclear imaging (PET/SPECT) or radioimmunotherapy (RIT) are active in CLI, provided that they emit energetic enough beta particles456789101112131415161718192021222324252627.…”

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confidence: 99%

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Redshifted Cherenkov Radiation for in vivo Imaging: Coupling Cherenkov Radiation Energy Transfer to multiple Förster Resonance Energy Transfers

Bernhard

Collin

Decréau

2017

Sci Rep

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Cherenkov Radiation (CR), this blue glow seen in nuclear reactors, is an optical light originating from energetic β-emitter radionuclides. CR emitter 90Y triggers a cascade of energy transfers in the presence of a mixed population of fluorophores (which each other match their respective absorption and emission maxima): Cherenkov Radiation Energy Transfer (CRET) first, followed by multiple Förster Resonance Energy transfers (FRET): CRET ratios were calculated to give a rough estimate of the transfer efficiency. While CR is blue-weighted (300–500 nm), such cascades of Energy Transfers allowed to get a) fluorescence emission up to 710 nm, which is beyond the main CR window and within the near-infrared (NIR) window where biological tissues are most transparent, b) to amplify this emission and boost the radiance on that window: EMT6-tumor bearing mice injected with both a radionuclide and a mixture of fluorophores having a good spectral overlap, were shown to have nearly a two-fold radiance boost (measured on a NIR window centered on the emission wavelength of the last fluorophore in the Energy Transfer cascade) compared to a tumor injected with the radionuclide only. Some CR embarked light source could be converted into a near-infrared radiation, where biological tissues are most transparent.

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Section: In Vivo Studies On the Optical Imagersupporting

confidence: 60%

mentioning

confidence: 98%

mentioning

confidence: 99%

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Redshifted Cherenkov Radiation for in vivo Imaging: Coupling Cherenkov Radiation Energy Transfer to multiple Förster Resonance Energy Transfers

Bernhard

Collin

Decréau

2017

Sci Rep

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“…Recently, Kotagiri et al demonstrated that using DNA as a spacer to control the distance between QD655 and 64 Cu produces the CL to excite the QDs [69]. To test the distance-dependent CL energy transfer, QD655 and 64 Cu distance was set between 1.15 nm to 31.15 nm using DNA as a linker.…”

Section: Internal Excitation Sourcementioning

confidence: 99%

Cerenkov radiation: a multi-functional approach for biological sciences

Wang

Cheng

2014

Front. Physics

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“…Enhancement of the Čerenkov signal is possible via interaction with radiation absorbing media, such as gold or copper based nanoparticles [70][71][72]. Several innovative designs in nanoparticle material science have shown that a carefully designed particle can enhance the signal, or this effect could be used for microenvironment sensing [73]. The self illuminating version of these, can be used for combined PET and NIR imaging, or be used for radiotherapy in situ with the potential for NIR imaging of the delivery.…”

Section: Molecules For čErenkov Sensing and Radiosensitizationmentioning

confidence: 99%

Review of biomedical Čerenkov luminescence imaging applications

Tanha

Pashazadeh

Pogue

2015

Biomed. Opt. Express

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Čerenkov radiation is a fascinating optical signal, which has been exploited for unique diagnostic biological sensing and imaging, with significantly expanded use just in the last half decade. Čerenkov Luminescence Imaging (CLI) has desirable capabilities for niche applications, using specially designed measurement systems that report on radiation distributions, radiotracer and nanoparticle concentrations, and are directly applied to procedures such as medicine assessment, endoscopy, surgery, quality assurance and dosimetry. When compared to the other imaging tools such as PET and SPECT, CLI can have the key advantage of lower cost, higher throughput and lower imaging time. CLI can also provide imaging and dosimetry information from both radioisotopes and linear accelerator irradiation. The relatively short range of optical photon transport in tissue means that direct Čerenkov luminescence imaging is restricted to small animals or near surface human use. Use of Čerenkov-excitation for additional molecular probes, is now emerging as a key tool for biosensing or radiosensitization. This review evaluates these new improvements in CLI for both medical value and biological insight. References and links 1. P. Čerenkov, "Visible radiation produced by electrons moving in a medium with velocities exceeding the of light," Phys. Rev. 52(4), 378-379 (1937). 2. P. Čerenkov, "Visible Emission of Člean Liquids by Action of $\gamma$ Radiation," Dokl. Akad. Nauk SSSR 2, 451-454 (1934). 3. R. H. Elrick and R. P. Parker, "The use of Cerenkov radiation in the measurement of beta-emitting radionuclides," Int. J. Appl. Radiat. Isot. 19(3), 263-271 (1968). 4. M. K. Johnson, "Counting of Čerenkov radiation from 32P in nonaqueous media," Anal. Biochem. 29(2), 348-350 (1969). 5. F. L. Hoch, R. A. Kuras, and J. D. Jones, "Iodine analysis of biological samples by neutron activation of 127-I, with scintillation counting of Čerenkov radiation," Anal. Biochem. 40(1), 86-94 (1971). 6. G. Bosia, C. Castagnoli, M. Dardo, and G. Marangoni, "Observation of structure in Čerenkov pulses from extensive air showers using fast techniques," Nature 225(5232), 532-533 (1970). 7. W. C. Haxton, "Salty water Čerenkov detectors for solar neutrinos," Phys. Rev. Lett. 76(10), 1562-1565 (1996). Chen, "PET and NIR optical imaging using self-illuminating (64)Cu-doped chelator-free gold nanoclusters," Biomaterials 35(37), 9868-9876 (2014). 72.

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Activatable Probes Based on Distance‐Dependent Luminescence Associated with Cerenkov Radiation

Cited by 15 publications

References 26 publications

Redshifted Cherenkov Radiation for in vivo Imaging: Coupling Cherenkov Radiation Energy Transfer to multiple Förster Resonance Energy Transfers

Redshifted Cherenkov Radiation for in vivo Imaging: Coupling Cherenkov Radiation Energy Transfer to multiple Förster Resonance Energy Transfers

Cerenkov radiation: a multi-functional approach for biological sciences

Review of biomedical Čerenkov luminescence imaging applications

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