Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis

Xie, Zheng; Wang, Xuan; Luo, Xiaoxiao; Yan, Junkai; Zhang, Jie; Luo, Ai-lun; Li, Shiyong

doi:10.1016/j.bcp.2022.115374

Cited by 30 publications

(8 citation statements)

References 68 publications

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“… 27 Noteworthy, increased iron uptake in hippocampal neurons in T2DM triggers cell death, and damage to multiple regions of the hippocampus may be involved. 28 Similar to neurons, hippocampal astrocytes in T2DM models have been found to exhibit iron hyperuptake and to be associated with astrocyte polarization. 29 This is an important finding, as iron transfer from the periphery into neurons is tightly regulated by astrocytes.…”

Section: Location Of Brain Iron Deposits In DCImentioning

confidence: 99%

The Role of Iron Overload in Diabetic Cognitive Impairment: A Review

An,

Wang,

Sun

et al. 2023

DMSO

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It is well documented that diabetes mellitus (DM) is strongly associated with cognitive decline and structural damage to the brain. Cognitive deficits appear early in DM and continue to worsen as the disease progresses, possibly due to different underlying mechanisms. Normal iron metabolism is necessary to maintain normal physiological functions of the brain, but iron deposition is one of the causes of some neurodegenerative diseases. Increasing evidence shows that iron overload not only increases the risk of DM, but also contributes to the development of cognitive impairment. The current review highlights the role of iron overload in diabetic cognitive impairment (DCI), including the specific location and regulation mechanism of iron deposition in the diabetic brain, the factors that trigger iron deposition, and the consequences of iron deposition. Finally, we also discuss possible therapies to improve DCI and brain iron deposition.

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Section: Location Of Brain Iron Deposits In DCImentioning

confidence: 99%

The Role of Iron Overload in Diabetic Cognitive Impairment: A Review

An,

Wang,

Sun

et al. 2023

DMSO

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“…Insulin resistance in the hippocampal tissue, with amyloid deposition, could also lead to neuronal damage, which could cause cognitive decline (Ertas et al., 2023 ). In addition, mitochondrial homeostasis imbalance, ferroptosis, and neuronal autophagy may also be potential mechanisms for diabetes‐induced cognitive impairment (Chang et al., 2023 ; Fakih et al., 2020 ; Tang et al., 2022 ; Xie et al., 2023 ; Zheng et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Diabetes and vascular mild cognitive impairment among Chinese ≥50 years: A cross‐sectional study with 2020 participants

Zhang,

Liu,

et al. 2024

Brain and Behavior

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BackgroundWith the decline of cognitive function in vascular cognitive impairment, the burden on the family and society will increase. Therefore, early identification of vascular mild cognitive impairment (VaMCI) is crucial. The focus of early identification of VaMCI is on the attention of risk factors. Therefore, this study aimed to investigate the relationship between diabetes and VaMCI among the Chinese, hoping to predict the risk of VaMCI by diabetes and to move the identification of vascular cognitive impairment forward.MethodsWe collected data from seven clinical centers and nine communities in China. All participants were over 50 years of age and had cognitive complaints. We collected basic information of the participants, and cognitive function was professionally assessed by the Montreal Cognitive Assessment scale. Finally, logistic regression analysis was used to analyze the correlation between each factor and VaMCI.ResultsA total of 2020 participants were included, including 1140 participants with VaMCI and 880 participants with normal cognition. In univariate logistic regression analysis, age, heavy smoking, and diabetes had a positive correlation with VaMCI. At the same time, being married, high education, and light smoking had a negative correlation with VaMCI. After correction, only diabetes (OR = 1.04, 95% CI: 1.01–1.09, p = 0.05) had a positive correlation with VaMCI, and high education (OR = 0.60, 95% CI:.45–.81, p = 0.001) had a negative correlation with VaMCI.ConclusionIn our study, we found that diabetes had a positive correlation with VaMCI, and high education had a negative correlation with VaMCI. Therefore, early identification and timely intervention of diabetes may reduce the risk of VaMCI and achieve early prevention of VaMCI.

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“…reported that AMPK activation could improve cognitive function by inhibiting hippocampal ferroptosis in diabetic mice. 31 However, whether the neuroprotective effect of melatonin on diabetic brain injury is associated with modulating neuronal ferroptosis has still not been determined. It is well known that blocking SLC7A11 can induce ferroptosis by triggering GSH inhibition and GPX4 inactivation.…”

Section: Discussionmentioning

confidence: 99%

A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury

Yu,

Zhang,

Zhu

et al. 2024

iScience

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Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis

Cited by 30 publications

References 68 publications

The Role of Iron Overload in Diabetic Cognitive Impairment: A Review

The Role of Iron Overload in Diabetic Cognitive Impairment: A Review

Diabetes and vascular mild cognitive impairment among Chinese ≥50 years: A cross‐sectional study with 2020 participants

A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury

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