Activated CD4-positive T-lymphocytes and impaired cell-mediated immunity in patients with carcinoma of the urinary bladder with schistosomiasis

Abstract

Patients with schistosomiasis of the urinary bladder (SB) associated with carcinoma of the bladder (SCB) or carcinoma of the prostate (SCP) have a variety of immunologic abnormalities, including the presence of HLA‐DR+ and interleukin‐2 receptor‐positive (IL‐2R+) T‐lymphocytes in circulating blood. This study demonstrated that, the HLA‐DR+ and IL‐2R+ antigens are selectively expressed on majority of the CD4+ T‐lymphocytes of patients with SCB, whereas, these antigens are expressed almost equally on both CD4+ and CD8+ T‐lymphocytes of patients with SB and SCP. Expressions of HLA‐DR+ and IL‐2R+ antigens in CD4+ T‐lymphocytes, and a depressed response of this T‐cell subset to phytohemagglutinin and Concanavalin A stimulations seems to be the characteristic feature of these patients with SCB. In addition, the autologous mixed lymphocyte reaction (AMLR) and allogenic mixed lymphocyte reaction (MLR) was depressed in patients with SCB. However, patients with SCP demonstrated a normal MLR, even though the AMLR was highly depressed. The immunoregulatory role of the HLA‐DR+, IL‐2R+, CD4+ helper/inducer T‐lymphocytes, and the AMLR and MLR abnormalities we have identified in patients with SCB may be important and could play a role in the pathobiology of these diseases in humans.

Phenotype, activation and lymphokine secretion by γ/δ T lymphocytes from schistosomiasis and carcinoma of the urinary bladder

“…The highly enhanced synthesis of two lymphokines, BCGF and BCDF by the CD3+ TcR y/6 cells from SCB patients appears to be an important intrinsic feature of the immune system in this disease. These results are in consistent with the impaired cell-mediated immunity [7], as well as the humoral antibody abnormality related to the hypergammaglobulinemia found in this disease [l-31. Therefore, the elevated secretion of BCGF and BCDF by the CD3+ TcR y/6 Tcells may have an pivotal role in the disease pathogenesis in SCB.…”

“…Correspondence: Syed Raziuddin, Department of Clinical Immunology, College of Medicine, PO. Box 641, Abha, Saudi Arabia Abbreviations: SB: Schistosomiasis of the urinary bladder SCB: Schistosomiasis with carcinoma of the urinary bladder BCGF B cell growth factor BCDF B cell differentiation factor SEA: Soluble egg antigen prehensive study documented the severe alterations in T cells subsets and the presence of increased percentages of activated CD4+ T cells in patients with schistosomiasis [7]. In the present study we sought to determine whether the expression of TcR might also be altered in schistosomiasis infection in humans.…”

“…The patients belonged to two groups: those with urinary bladder schistosomiasis without any malignant change (SB), and those with SCB. In both SB and SCB patients, the diagnosis was based on radiological investigations and histopathology [7]. All biopsy specimens showed characteristic eggs of S. haematobium, many calcified, with infiltration by chronic inflammatory cells in the submucosa.…”

Human papillomavirus, coinfection with Schistosoma hematobium, and cervical neoplasia in rural Tanzania

“…The observed increased frequency of HPV infections and HPVassociated CIN II/III among women with either a history of or active bilharzias fits both hypotheses although the numbers of high-grade neoplasia are too small to prove which is the correct model. Schistosomiasis induced tissue damage, immune impairment, and chromosome breakage are discussed as etiologic factors of bladder cancer (7,14,15) ; and similarly could contribute to the development of genital neoplasia as proposed by others (16) . However Schistosoma hematobium ova were only detected in the histologic slides of three invasive cancers (Fig.…”

Soluble Interleukin‐2 Receptor Levels and Immune Activation in Patients with Schistosomiasis and Carcinoma of the Urinary Bladder

“…Carcinoma ofthe urinary bladder is one ofthe frequent malignancies worldwide and the most common disease in Saudi Arabia and many tropical countries. There is some evidence to suggest that schistosomiasis, a parasitic human infection {Schistosoma haematobium), is implicated as an aetiologic agent in carcinoma of the urinary bladder [1][2][3]. Schistosomiasis affects about 200 million people worldwide [1].…”