Activated CD56+ lymphocytes (NK+NKT) mediate immunomodulatory and anti-viral effects during Japanese encephalitis virus infection of dendritic cells in-vitro

Sooryanarain, Harini; Ayachit, Vijay M.; Gore, Milind M.

doi:10.1016/j.virol.2012.05.013

Cited by 16 publications

(20 citation statements)

References 53 publications

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“…Indeed, CD56 expression has been correlated with anti‐CD3‐induced cytotoxic function in CD8 + T cells from healthy subjects and in human papillomavirus‐specific CD8 + T cells . CD56 + T cells have been implicated as effector cells in protection against HIV, hepatitis C virus and Japanese encephalitis virus, as well as the autoimmune inflammatory condition Behçet's disease . Also, CD4 + CD28 − CD56 + cells were expanded in patients with chronic hepatitis B virus infection and mast cell stimulation by reovirus was found to lead to recruitment of CD56 + T cells in vitro …”

Section: Discussionmentioning

confidence: 99%

Increased numbers and functional activity of CD56⁺T cells in healthy cytomegalovirus positive subjects

et al. 2014

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Human T cells expressing CD56 are capable of tumour cell lysis following activation with interleukin-2 but their role in viral immunity has been less well studied. Proportions of CD56(+) T cells were found to be highly significantly increased in cytomegalovirus-seropositive (CMV(+) ) compared with seronegative (CMV(-) ) healthy subjects (9.1 ± 1.5% versus 3.7 ± 1.0%; P < 0.0001). Proportions of CD56(+) T cells expressing CD28, CD62L, CD127, CD161 and CCR7 were significantly lower in CMV(+) than CMV(-) subjects but those expressing CD4, CD8, CD45RO, CD57, CD58, CD94 and NKG2C were significantly increased (P < 0.05), some having the phenotype of T effector memory cells. Levels of pro-inflammatory cytokines and CD107a were significantly higher in CD56(+) T cells from CMV(+) than CMV(-) subjects following stimulation with CMV antigens. This also resulted in higher levels of proliferation in CD56(+) T cells from CMV(+) than CMV(-) subjects. Using Class I HLA pentamers, it was found that CD56(+) T cells from CMV(+) subjects contained similar proportions of antigen-specific CD8(+) T cells to CD56(-) T cells in donors of several different HLA types. These differences may reflect the expansion and enhanced functional activity of CMV-specific CD56(+) memory T cells. In view of the link between CD56 expression and T-cell cytotoxic function, this strongly implicates CD56(+) T cells as being an important component of the cytotoxic T-cell response to CMV in healthy carriers.

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Section: Discussionmentioning

confidence: 99%

Increased numbers and functional activity of CD56⁺T cells in healthy cytomegalovirus positive subjects

et al. 2014

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“…Other virus infections have been found to lead to expansion of CD56+ T cells, including Japanese encephalitis virus and human immunodeficiency virus , so the effects reported here may not be specific to CMV. Indeed, both EBV and BK virus may take advantage of the immunosuppression in transplant patients and proliferate.…”

Section: Discussionmentioning

confidence: 77%

CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection

Almehmadi

Hammad

Heyworth

et al. 2015

Transplant Infectious Dis

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“…NK cells have been reported to be involved in the host immunity to infection of many flaviviruses, including yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, dengue virus, and WNV [23,24,25,26]. Vargin et al .…”

Section: Nk Cellsmentioning

confidence: 99%

Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection

Welte

2013

Viruses

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Natural Killer (NK) cells and Gamma-delta T cells are both innate lymphocytes that respond rapidly and non-specifically to viral infection and other pathogens. They are also known to form a unique link between innate and adaptive immunity. Although they have similar immune features and effector functions, accumulating evidence in mice and humans suggest these two cell types have distinct roles in the control of infection by West Nile virus (WNV), a re-emerging pathogen that has caused fatal encephalitis in North America over the past decade. This review will discuss recent studies on these two cell types in protective immunity and viral pathogenesis during WNV infection.

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Activated CD56+ lymphocytes (NK+NKT) mediate immunomodulatory and anti-viral effects during Japanese encephalitis virus infection of dendritic cells in-vitro

Cited by 16 publications

References 53 publications

Increased numbers and functional activity of CD56⁺T cells in healthy cytomegalovirus positive subjects

Increased numbers and functional activity of CD56⁺T cells in healthy cytomegalovirus positive subjects

CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection

Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection

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Activated CD56+ lymphocytes (NK+NKT) mediate immunomodulatory and anti-viral effects during Japanese encephalitis virus infection of dendritic cells in-vitro

Cited by 16 publications

References 53 publications

Increased numbers and functional activity of CD56+T cells in healthy cytomegalovirus positive subjects

Increased numbers and functional activity of CD56+T cells in healthy cytomegalovirus positive subjects

CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection

Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection

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Increased numbers and functional activity of CD56⁺T cells in healthy cytomegalovirus positive subjects

Increased numbers and functional activity of CD56⁺T cells in healthy cytomegalovirus positive subjects