Activated charcoal for pediatric poisonings: the universal antidote?

Lapus, Robert M.

doi:10.1097/mop.0b013e32801da2a9

Cited by 31 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If used, dosing of activated charcoal is weight-based. In children, the dose is 0.5-1 g activated charcoal/kilogram to a maximum dose of 50 g. Typical adult and adolescent dosing ranges from 25 to 100 g (Lapus, 2007). For single-dosing regimens of activated charcoal, sorbitol is not routinely indicated.…”

Section: Activated Charcoalmentioning

confidence: 99%

Toxicology in the Emergency Department

Gresham

Wilbeck

2012

Advanced Emergency Nursing Journal

View full text Add to dashboard Cite

General assessment, resuscitation strategies, and risk assessment of the poisoned patient are explored in this article, including specific interventions for unresponsive patients and seizures. Sympathomimetic and anticholinergic toxidromes are described in terms of clinical presentation and treatment strategies and are compared with other common toxidromes. Controversies in gastric decontamination are also outlined, including consensus panel and national organizational recommendations. Despite available methods for toxin elimination, advances in medicine, and pharmacotherapy options, the cornerstone of toxicology remains supportive care. The purpose of this article is to equip the advanced practice nurse in the emergency setting with baseline knowledge to provide initial care of the poisoned patient.

show abstract

Section: Activated Charcoalmentioning

confidence: 99%

Toxicology in the Emergency Department

Gresham

Wilbeck

2012

Advanced Emergency Nursing Journal

View full text Add to dashboard Cite

show abstract

“…This property encouraged scientists in the pharmaceutical field to use it as an antidote for a drug poisoning. It is used for flatulent treatment, and as a good treatment for reducing blood lipid concentrations in patients with uremia and diabetes [7]. It is also used for the adsorption of odors from wounds [8].…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Evaluation of Activated Charcoal as a Poison Antidote for Gliclazide Drug

Hassen

Ayfan

Farhan

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective:The aim of the present study is to evaluate the ability of activated charcoal in adsorbing overdosage of gliclazide drug, and to study the effects of pH, concentration and time on this process. Methods:To evaluate the effect of pH, concentration and time; 50 ml of the drug solution (100 mg/L) were allowed to stand with the activated charcoal for 1 h at pH of 1.5, 4, 7, and 9 for pH study. 50 ml of the drug solution concentrations of 25, 50, 75, and 100 (mg/L) were allowed to stand with 1 g activated charcoal for 1 h for concentration study. 50 mg of the drug solution (100 mg/L) were allowed to stand with the activated charcoal for 15, 30, 45, and 60 min for time study. The concentrations of the adsorbed drug were determined spectrophotometrically. Results:The adsorption of the gliclazide drug on activated charcoal was found to be pH, concentration, and time-dependent. The amounts of the drug adsorbed were 3, 0.75, 0.6, and 0.5 mg/g for pHs 1.5, 4, 7, and 9, respectively, for pH study. For concentration study, the amounts adsorbed were 0.15, 0.22, 0.33, and 0.58 mg/g for concentrations 25, 50, 75, and 100 mg/L, respectively. For time study, the amounts were 0.3, 0.4, 0.51, and 0.65 mg/g for reaction times 15, 30, 45, and 60 min, respectively. Conclusion:The best adsorption circumstances of gliclazide drug on activated charcoal that were found; acidic pH, a high concentration of the drug and longtime of contact.

show abstract

“…Activated charcoal (AC) may be used but its efficacy is controversial in case of mercury poisoning. The usual oral dose of AC is 0.5-1 gr/kg, with a maximum dose of 100 gr [69]. Many organic and inorganic contaminants are removed with this method [70].…”

Section: Introductionmentioning

confidence: 99%

“…It is believed that AC has been used to absorb different agents, except hydrocarbons, acids-alkalis, ethanol and heavy metal. Unlike in the cases of heavy metal poisoning, charcoal tightly binds with metallic compounds [38,69]. …”

Section: Introductionmentioning

confidence: 99%

Current approaches of the management of mercury poisoning: need of the hour

Rafati-Rahimzadeh

Kazemi

et al. 2014

DARU J Pharm Sci

View full text Add to dashboard Cite

Mercury poisoning cases have been reported in many parts of the world, resulting in many deaths every year. Mercury compounds are classified in different chemical types such as elemental, inorganic and organic forms. Long term exposure to mercury compounds from different sources e.g. water, food, soil and air lead to toxic effects on cardiovascular, pulmonary, urinary, gastrointestinal, neurological systems and skin. Mercury level can be measured in plasma, urine, feces and hair samples. Urinary concentration is a good indicator of poisoning of elemental and inorganic mercury, but organic mercury (e.g. methyl mercury) can be detected easily in feces. Gold nanoparticles (AuNPs) are a rapid, cheap and sensitive method for detection of thymine bound mercuric ions. Silver nanoparticles are used as a sensitive detector of low concentration Hg2+ ions in homogeneous aqueous solutions. Besides supportive therapy, British anti lewisite, dimercaprol (BAL), 2,3-dimercaptosuccinic acid (DMSA. succimer) and dimercaptopropanesulfoxid acid (DMPS) are currently used as chelating agents in mercury poisoning. Natural biologic scavengers such as algae, azolla and other aquatic plants possess the ability to uptake mercury traces from the environment.

show abstract

Activated charcoal for pediatric poisonings: the universal antidote?

Cited by 31 publications

References 39 publications

Toxicology in the Emergency Department

Toxicology in the Emergency Department

Spectroscopic Evaluation of Activated Charcoal as a Poison Antidote for Gliclazide Drug

Current approaches of the management of mercury poisoning: need of the hour

Contact Info

Product

Resources

About