2022
DOI: 10.14336/ad.2021.1212
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Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases

Abstract: As the population ages, age-related neurodegenerative diseases have become a major challenge in health science. Currently, the pathology of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, is still not fully understood. Remarkably, emerging evidence indicates a role of genomic DNA damage and repair in various neurodegenerative disorders. Here, we summarized the current understanding of the function of DNA damage repair, espec… Show more

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Cited by 11 publications
(8 citation statements)
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“…We show here that TET3 is an important regulator of mitochondrial function and that EndoG is a direct target of its catalytic activity. Given the known roles of ENDOG in the DDR [ 67 , 68 ] and the emerging link between DDR linked to mitochondrial dysfunction and neurodegenerative diseases [ 71 , 76 ], these findings may therefore prove to be of future clinical importance.…”
Section: Discussionmentioning
confidence: 99%
“…We show here that TET3 is an important regulator of mitochondrial function and that EndoG is a direct target of its catalytic activity. Given the known roles of ENDOG in the DDR [ 67 , 68 ] and the emerging link between DDR linked to mitochondrial dysfunction and neurodegenerative diseases [ 71 , 76 ], these findings may therefore prove to be of future clinical importance.…”
Section: Discussionmentioning
confidence: 99%
“…Although the evidence of DNA damage in PD has long been reported, the mechanisms of DNA repair in PD are only beginning to be understood [ 75 ]. Unlike other age-related neurodegenerative diseases, many DNA repair proteins are upregulated in the brains of PD patients and animal models, which is partially explained by DNA damage-induced repair activation [ 15 , 75 ]. Conversely, a growing body of studies suggests that DNA repair is defective in PD [ 14 , 15 ].…”
Section: Cause Of Dna Damage In Pdmentioning
confidence: 99%
“…Malfunctions in the DNA repair machinery are linked to various disorders, including neurodegeneration 41,42 . Notably, deficiencies in DNA DSB repair pathways have been suggested to cause adverse effects on neural development and neurogenesis 43,44 .…”
Section: Introductionmentioning
confidence: 99%