Activated sterically strained C=N bond in N-substituted p-quinone mono- and diimines: XV. Synthesis, structure, and reactions with alcohols of N-carbamoyl-1,4-benzoquinone imines

A practically simple, mild and efficient method is developed for the synthesis of N-substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N-substituted ureas (mono-, di-and cyclic-) were synthesized in good to excellent yields with high chemical purity by applying simple filtration or routine extraction procedures avoiding silica gel purification. The developed methodology was also found to be suitable for gram scale synthesis of molecules having commercial application in large volumes. The identified reaction conditions were found to promote a unique substrate selectivity from a mixture of two amines.

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A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

Tiwari

Kumar

Mahajan

2018

RSC Adv.

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Activated Sterically Strained C=N Bond in N-Substituted p-Quinone Mono- and Diimines: XVI. Structural Characteristics

2018

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Synthesis of 1,3-Benzoxathiol-2-one Derivatives from N-(4-Oxocyclohexa-2,5-dien-1-ylidene)ureas

et al. 2020

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Activated sterically strained C=N bond in N-substituted p-quinone mono- and diimines: XV. Synthesis, structure, and reactions with alcohols of N-carbamoyl-1,4-benzoquinone imines

Cited by 6 publications

References 23 publications

A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

Activated Sterically Strained C=N Bond in N-Substituted p-Quinone Mono- and Diimines: XVI. Structural Characteristics

Synthesis of 1,3-Benzoxathiol-2-one Derivatives from N-(4-Oxocyclohexa-2,5-dien-1-ylidene)ureas

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