Activated T cells and cytokine-induced CD3 + CD56 + killer cells

Schmidt-Wolf, Gabriele; Negrin, Robert S.; Schmidt‐Wolf, Ingo G.H.

doi:10.1007/s002770050257

Cited by 124 publications

(77 citation statements)

References 31 publications

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“…Although CD56 ϩ lymphocytes are derived from multiple lineages, they share a functional association with immunosurveillance and antitumor responses (1,21,22). By understanding the pathways by which these cell types traffic throughout the body, we can begin to decipher the mechanisms by which these cells locate and infiltrate neoplasias.…”

Section: Discussionmentioning

confidence: 99%

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Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

Campbell

Qin

Unutmaz

et al. 2001

The Journal of Immunology

466

409

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CD56, an adhesion molecule closely related to neual cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLs. Although CD56+ cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. We have studied the chemokine receptor expression patterns and functional migratory responses of three distinct CD56+ populations from human peripheral blood. NK-T cells were found to differ greatly from NK cells, and CD16+ NK cells from CD16− NK cells. CD16+ NK cells were the predominant population responding to IL-8 and fractalkine, whereas NK-T cells were the predominant population responding to the CCR5 ligand macrophage-inflammatory protein-1β. CD16− NK cells were the only CD56+ population that uniformly expressed trafficking molecules necessary for homing into secondary lymphoid organs through high endothelial venule. These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types.

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Section: Discussionmentioning

confidence: 99%

“…CD56 ϩ lymphocytes are believed to be major players in immunosurveillance and antitumor responses (1,21,22). Thus, the mechanisms by which these cells home into tumors and areas of inflammation are of great relevance to human health and disease.…”

mentioning

confidence: 99%

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

Campbell

Qin

Unutmaz

et al. 2001

The Journal of Immunology

466

409

View full text Add to dashboard Cite

show abstract

“…11,12 In another SCID mouse model, CD3 + CD56 + cells from patients with chronic myelogenous leukemia were shown to have potent efficacy against autologous tumor cells. 13 The anti-tumor efficacy of some immune cells is known to involve perforin, and several studies have shown high levels of perforin expression in CD3 + CD56 + cells.…”

Section: Discussionmentioning

confidence: 99%

Numbers and cytotoxicities of CD3⁺CD56⁺T lymphocytes in peripheral blood of patients with acute myeloid leukemia and acute lymphocytic leukemia

Guo

Chen

Dong

et al. 2013

Cancer Biology & Therapy

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“…Die Ko ex pres si on von CD3 und CD56 de fi niert eine im pe ri phe ren Blut sel ten vor kom men de T-Zel le (1-5 der ge samten Lym pho zy ten po pu la ti on), die nicht MHC-re strin giert ist [23]. Eine wei te re selte ne Zell po pu la ti on bil den die sog.…”

Section: Sub Po Pu La Tio Nen Mit Mar Kern Für Nk-und T-zel Lenunclassified

Bedeutung der Bestimmung von Lymphozyten-Subpopulationen in der Umweltmedizin

2006

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz

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Be deu tung der Be stim mung von Lym pho zy ten-Sub po pu latio nen in der Um welt me di zin Mit tei lung der Kom mis si on "Me tho den und Qua li täts si che rung in der Um welt me di zin" Bundesgesundheitsbl -GesundheitsforschGesundheitsschutz 2006 · 49:468-484 DOI 10.1007/s00103-006-1248 Ein lei tungUm welter kran kun gen wer den im mer wie der mit Al te ra tio nen im mu no lo gischer Pro zes se in Ver bin dung ge bracht [2]. In den letz ten Jah ren stan den im Focus des In ter es ses mög li che Aus wir kungen um welt me di zi ni scher Ex po si tio nen auf die re la ti ven An tei le von Lym pho zyten-Sub po pu la tio nen. De ren An a ly se mittels Durch fluss zy to me trie an hand spe zi fischer Ober flä chen mar ker ist heu te -noch vor dem Lym pho zy ten trans for ma ti ons test (LTT) und der Be stim mung von Zy to kinen -die Haupt me tho de der im mu no logi schen zel lu lä ren Di ag nos tik (. Abb. 1) und hat da her auch in die Di ag nos tik von Um welter kran kun gen Ein gang ge fun den [3]. Schon lan ge ist be kannt, dass die Lympho zy ten in Un ter grup pen ein ge teilt werden müs sen (T-, B-und na tür li che Kil lerzel len), aber erst seit dem nach ge wie sen wur de, dass sie durch de fi nier te Ober flä-chen mo le kü le cha rak te ri siert sind, war es mög lich ge wor den, sie mit tels aus ge feilter Me tho den wie der Durch fluss zy to metrie zu be stim men. Ver än de run gen in der An zahl ein zel ner Sub po pu la tio nen kann man vor al lem bei Im mun de fek ten, Leukämi en, Au toim mun-und all er gi schen Erkran kun gen so wie bei Man gel-/Stoff wechse ler kran kun gen be obach ten [4,5,6]. Beson ders bei der Klas si fi zie rung von Leukämi en kommt die ser Me tho de große Bedeu tung zu.Auf den Stel len wert der Be stim mung von Lym pho zy ten-Sub po pu la tio nen bei um welt me di zi ni schen Fra ge stel lun gen soll in die ser Stel lung nah me ein ge gangen wer den, un ter be son de rer Be rück-sich ti gung der Ein flüs se von che mi schen Sub stan zen und phy si ka li schen Fak to ren. Auf bio lo gi sche Agen ti en (z. B. Schim melpil ze) wird hier nicht ein ge gan gen, da diese das The ma wei te rer Ab hand lun gen der o. g. Kom mis si on des RKI sein sol len. CD-No men kla turZel len be sit zen Ober flä chen mo le kü le, die über mo no klo na le An ti kör per iden tifi ziert und da mit auch be stimm ten Zellent wick lun gen zu ge ord net wer den kön-nen. Mo no klo na le An ti kör per, die gleiche Ober flä chen struk tu ren er ken nen, wer den in in ter na tio na len Work shops einem "Clus ter of Dif fe ren tia ti on" (CD) zuge ord net. Dies ver ein facht die Klas si fi zierung von Mo le kü len, die in ver schie de nen Fach dis zi pli nen mit un ter schied li chen Primär na men be nannt wer den. Mit der 8. Revi si on wur den wei te re Clus ter auf ge nommen, wo mit -bei Ver bleib von frei en Posi tio nen für er war te te zu sätz li che Mo lekü le ein zel ner Mo le kül grup pen -be reits CD339 er reicht wur de (8th In ter na tio nal Work shop and Con fe rence on Hu man Leuko cy te Dif fe ren...

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Activated T cells and cytokine-induced CD3 + CD56 + killer cells

Cited by 124 publications

References 31 publications

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

Numbers and cytotoxicities of CD3⁺CD56⁺T lymphocytes in peripheral blood of patients with acute myeloid leukemia and acute lymphocytic leukemia

Bedeutung der Bestimmung von Lymphozyten-Subpopulationen in der Umweltmedizin

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Activated T cells and cytokine-induced CD3 + CD56 + killer cells

Cited by 124 publications

References 31 publications

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

Numbers and cytotoxicities of CD3+CD56+T lymphocytes in peripheral blood of patients with acute myeloid leukemia and acute lymphocytic leukemia

Bedeutung der Bestimmung von Lymphozyten-Subpopulationen in der Umweltmedizin

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Numbers and cytotoxicities of CD3⁺CD56⁺T lymphocytes in peripheral blood of patients with acute myeloid leukemia and acute lymphocytic leukemia