Activating brown adipose tissue through exercise (ACTIBATE) in young adults: Rationale, design and methodology

Sánchez-Delgado, Guillermo; Martínez-Téllez, Borja; Olza, Josune; Aguilera, Concepción M.; Labayen, Idoia; Ortega, Francisco B.; Chillón, Palma; Fernandez-Reguera, Carlos; Alcantara, Juan M. A.; Martinez-Avila, Wendy D.; Muñoz-Hernández, Victoria; Acosta, Francisco M.; Prados-Ruiz, Juan Lorenzo; Amaro-Gahete, Francisco J.; Hidalgo-García, Laura; Rodríguez, Lorena; Ruiz, Yasmeen Abdel-Karim; Ramírez-Navarro, A.; Fuentes, Maria Angeles; Garcia-Rivero, Yolanda; Sánchez, R. Sánchez; Jimenez, Juan de Dios Beas; Teresa, Carlos de; Navarrete, Socorro; Lozano, Rosa M.; Brea-Gomez, Esther; Rubio-López, José; Ruiz, Maria R.; Cano-Nieto, Amalia; Elvira, J.M. Llamas; Ríos, José Antonio Jiménez; Gil, Ángel; Ruiz, Jonatan R.

doi:10.1016/j.cct.2015.11.004

Cited by 100 publications

(133 citation statements)

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“…More studies are needed to test these hypotheses [18], and if confirmed, new strategies have to be designed to counteract the BAT ‘side effect' of exercise-based therapies for preventing and treating obesity and related comorbidities.…”

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confidence: 99%

Is Brown Adipose Tissue-Mediated Adaptive Thermogenesis the Missing Component of the Constrained Total Energy Expenditure Model?

Sánchez-Delgado

Martínez-Téllez²,

Gil³

et al. 2016

Ann Nutr Metab

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confidence: 99%

Is Brown Adipose Tissue-Mediated Adaptive Thermogenesis the Missing Component of the Constrained Total Energy Expenditure Model?

Sánchez-Delgado

Martínez-Téllez²,

Gil³

et al. 2016

Ann Nutr Metab

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“…Yet when assessing individual participant data (Figure 1a, 1b, 1c) there was considerable variability evident between participants. The data variations could be explained by participants altering their dietary habits or physical exercise which have the potential of modifying body composition [11]. Further, participant's baseline BMI classification may have impacted this whereby those with higher BMIs had the potential for greater losses.…”

Section: Discussionmentioning

confidence: 99%

Brace yourselves, winter is coming: a pilot study of the effects of brief, infrequent cold water immersion upon body composition in young adult males

Wash¹

2017

jevohealth

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Background: The existence of functioning brown adipose tissue (BAT) in adult humans has brought into question the possibility of utilising the BAT mechanism as an obesity tackling strategy. This pilot study examined the effects of a short-term (6wk) cold water immersion (CWI) programme on the body composition of (n=10) healthy male adults. It was hypothesized that the thermal stresses would produce reductions in fat mass (FM) and body fat percentage (BFp) as a result of thermogenic activation of the BAT mechanism. Methods: Using a single arm prospective trial design, participants were subjected to singular acute (18min) cold water exposures (15±1°C) weekly for the duration of the intervention (6wk). Results: Nonsignificant decreases were observed in FM (-1.55±2.24kg; p = 0.057) and BFp (-1.62±2.46%; p = 0.067), and significant increases in fat free mass (FFM; 1.46±1.68kg; p = 0.023). Conclusions: The results indicate that the intervention could be adopted as a plausible method to exert positive changes to body composition. These findings should stimulate follow up studies to examine the interventions efficacy in a larger more representative sample and examine its feasibility of implementation as a genuine obesity tackling strategy.

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“…A total of 90 ( n = 65 women) healthy adults aged 21.9 (SD 2.3) years participated in the present study (Table ). The participants were enrolled in the Activating Brown Adipose Tissue Through Exercise (ACTIBATE) study , an exercise‐based randomized controlled trial (ClinicalTrials.gov identifier NCT02365129). All participants were nonsmokers, were not enrolled in a weight loss program, had a stable body weight (body weight changes < 3 kg) over the previous 3 months, were not physically active (< 20 minutes on < 3 d/wk), did not take any medication, had no acute or chronic illness, and reported not being regularly exposed to cold.…”

Section: Methodsmentioning

confidence: 99%

The Mediating Role of Brown Fat and Skeletal Muscle Measured by ¹⁸F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults

Martínez-Téllez

Adelantado‐Renau

Acosta

et al. 2019

Obesity

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Objective This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal‐ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal‐ET and WT (as a proxy of peripheral vasoconstriction/vasodilation). Methods The levels of BAT were quantified by cold‐induced 18F‐fluorodeoxyglucose–positron emission tomography/computed tomography scan and measured the Personal‐ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74.6% women). Results The study found that BAT volume and metabolic activity played a positive and significant role (up to 25.4%) in the association between Personal‐ET and WT. In addition, at the coldest temperatures, the participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle activity. Conclusions BAT volume and metabolic activity play a role in the relationship between Personal‐ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat.

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Activating brown adipose tissue through exercise (ACTIBATE) in young adults: Rationale, design and methodology

Cited by 100 publications

References 63 publications

Is Brown Adipose Tissue-Mediated Adaptive Thermogenesis the Missing Component of the Constrained Total Energy Expenditure Model?

Is Brown Adipose Tissue-Mediated Adaptive Thermogenesis the Missing Component of the Constrained Total Energy Expenditure Model?

Brace yourselves, winter is coming: a pilot study of the effects of brief, infrequent cold water immersion upon body composition in young adult males

The Mediating Role of Brown Fat and Skeletal Muscle Measured by ¹⁸F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults

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Activating brown adipose tissue through exercise (ACTIBATE) in young adults: Rationale, design and methodology

Cited by 100 publications

References 63 publications

Is Brown Adipose Tissue-Mediated Adaptive Thermogenesis the Missing Component of the Constrained Total Energy Expenditure Model?

Is Brown Adipose Tissue-Mediated Adaptive Thermogenesis the Missing Component of the Constrained Total Energy Expenditure Model?

Brace yourselves, winter is coming: a pilot study of the effects of brief, infrequent cold water immersion upon body composition in young adult males

The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults

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The Mediating Role of Brown Fat and Skeletal Muscle Measured by ¹⁸F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults