Activating KIR/HLA-I combinations as a risk factor of adult B-ALL

Halimi, Hossein; Mirzazadeh, Sara; Kalantar, Kurosh; Hajimaghsoodi, Maryam; Ramzi, Mani; Farjadian, Shirin

doi:10.1016/j.humimm.2024.110750

Human Immunology

2024

DOI: 10.1016/j.humimm.2024.110750

|View full text |Cite

Activating KIR/HLA-I combinations as a risk factor of adult B-ALL

Hossein Halimi,

Sara Mirzazadeh,

Kurosh Kalantar

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Effects of Cancer Immunotherapy on Fertility: Focus on Hematological Malignancies

Caserta,

Cancemi,

Murdaca

et al. 2024

Biomedicines

View full text Add to dashboard Cite

In recent years, cancer management has benefitted from new effective treatments, including immunotherapy. While these therapies improve cancer survival rates, they can alter immune responses and cause long-term side effects, of which gonadotoxic effects and the potential impact on male and female fertility are growing concerns. Immunotherapies, such as immune checkpoint inhibitors, immunomodulators, monoclonal antibodies, and CAR-T, can lead to elevated levels of proinflammatory cytokines and immune-related adverse events that may exacerbate fertility problems. Immunotherapy-related inflammation, characterized by cytokine imbalances and the activation of pathways such as AMPK/mTOR, has been implicated in the mechanisms of fertility impairment. In men, hypospermatogenesis and aspermatogenesis have been observed after treatment with immune checkpoint inhibitors, by direct effects on the gonads, particularly through the inhibition of cytotoxic T lymphocyte antigen-4. In women, both damage to ovarian reserves, recurrent pregnancy loss, and implantation failure have been documented, secondary to a complex interplay between immune cells, such as T cells and uterine NK cells. In this review, the impact of immunotherapy on fertility in patients with hematological cancers was analyzed. While this area is still underexplored, fertility preservation methods remain crucial. Future studies should investigate immunotherapy’s effects on fertility and establish standardized preservation protocols.

show abstract

The Effects of Cancer Immunotherapy on Fertility: Focus on Hematological Malignancies

Caserta,

Cancemi,

Murdaca

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Activating KIR/HLA-I combinations as a risk factor of adult B-ALL

Cited by 1 publication

References 31 publications

The Effects of Cancer Immunotherapy on Fertility: Focus on Hematological Malignancies

The Effects of Cancer Immunotherapy on Fertility: Focus on Hematological Malignancies

Contact Info

Product

Resources

About