2018
DOI: 10.1128/jvi.00114-18
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Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response

Abstract: There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. The antibody response is critical for vaccine-induced protection, and T follicular helper cells (TFH) are considered important for mediating the antibody response. Most data supporting the role for TFH in the antibody response are from animal studies, and direct evidence from humans is limited, apart from the presence of TFH-like cells in blood. We studied the activation and induction of TFH and their … Show more

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Cited by 42 publications
(34 citation statements)
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“…Circulating T follicular helper cells are therefore considered a promising target to improve vaccination strategies 17 . While the CD8 + T cell response to YFV has been described in detail previously, 18‐20 the CD4 + T cell response has only recently drawn attention 21 .…”
Section: Introductionmentioning
confidence: 99%
“…Circulating T follicular helper cells are therefore considered a promising target to improve vaccination strategies 17 . While the CD8 + T cell response to YFV has been described in detail previously, 18‐20 the CD4 + T cell response has only recently drawn attention 21 .…”
Section: Introductionmentioning
confidence: 99%
“…This immunity is conveniently measured as haemagglutination inhibition (HAI) for those viruses that exhibit haemagglutination. In addition, LAIV induces immune responses to NA as well as HA, local IgA and influenza specific resident memory CD4+ and CD8+ T cells 11,49,50 that may contribute to local mucosal defences. These forms of immunity may be more important than the induction of systemic antibody, a current regulatory requirement for conventional parenteral influenza vaccines.…”
Section: Influenza Vaccinesmentioning
confidence: 99%
“…The products of the GC reaction are memory B cells and long-lived plasma cells that secrete high-affinity antibodies [22]. Mounting evidence suggests a strong correlation between the frequencies of Tfh cells and antigen-specific antibody responses, and more importantly, it was further proved in the human immune system [52]. Except for the inducement of Tfh proliferation, MAP-TB immunization also induced an elevation of IL-6 which has been shown to be an important regulator for the differentiation of Tfh cells [53].…”
Section: Journal Of Immunology Researchmentioning
confidence: 99%