Activation and inhibition of calcium‐dependent histamine secretion by ATP ions applied to rat mast cells.

Cockcroft, Shamshad; Gomperts, Bastien D.

doi:10.1113/jphysiol.1979.sp013002

Cited by 145 publications

(88 citation statements)

References 26 publications

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“…RBL-2H3 and rat peritoneal mast cells indeed express functional P2Y, P2X 1 , and P2X 7 receptors as was shown indirectly by pharmacological studies [7,[60][61][62][63][64].…”

Section: Expression Of P2 Receptors On Mast Cellsmentioning

confidence: 86%

“…Importantly, P2X 7 receptor activation leads to the opening of a nonselective pore permeable to large organic molecules (choline (100 Da), ethidium bromide (314 Da), YO-PRO-1 (376 Da), propidium iodide (414 Da), Lucifer Yellow (457 Da), and ATP itself (605 Da)) [5,40,60]. The ability to open such pore is an exclusive feature of the P2X 7 receptor.…”

Section: P2 Receptor-mediated Responses Of Mast Cellsmentioning

confidence: 99%

“…Pannexin-1 co-associates with P2X 7 , and this complex is not only essential for P2X 7 -induced dye uptake without altering Ca 2+ influx but also for the caspase-1 processing and release of mature IL-1β [67,68]. Degranulation ATP has long been known to induce histamine release from mast cells [3][4][5][60][61][62][63]. In 1979, Cockcroft and Gomperts have shown that ATP caused Ca 2+ -dependent histamine release and striking morphological changes in rat mast cells [5,60].…”

Section: P2 Receptor-mediated Responses Of Mast Cellsmentioning

confidence: 99%

“…Degranulation ATP has long been known to induce histamine release from mast cells [3][4][5][60][61][62][63]. In 1979, Cockcroft and Gomperts have shown that ATP caused Ca 2+ -dependent histamine release and striking morphological changes in rat mast cells [5,60]. ATP 4− induced histamine release at a concentration of ∼3 μM, while at higher concentrations (>5 mM), degranulation was inhibited due to increased membrane permeabilization and leakage of larger molecules, including nucleotides [5].…”

Section: P2 Receptor-mediated Responses Of Mast Cellsmentioning

confidence: 99%

“…There is a tight cross-communication between neurons and mast cells which will be discussed below. ATP not only directly induces degranulation of mast cells but also modulates IgE/ antigen-mediated degranulation [60][61][62]70]. Moreover, ATP and other nucleotides are potent chemoattractants [48].…”

Section: Purinergic Signaling In Allergic Airway Inflammation: Focus mentioning

confidence: 99%

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P2 receptor-mediated signaling in mast cell biology

Bulanova

Bulfone–Paus∥

2009

Purinergic Signalling

101

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Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and antitumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system.

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“…RBL-2H3 and rat peritoneal mast cells indeed express functional P2Y, P2X 1 , and P2X 7 receptors as was shown indirectly by pharmacological studies [7,[60][61][62][63][64].…”

Section: Expression Of P2 Receptors On Mast Cellsmentioning

confidence: 86%

Section: P2 Receptor-mediated Responses Of Mast Cellsmentioning

confidence: 99%

Section: P2 Receptor-mediated Responses Of Mast Cellsmentioning

confidence: 99%

Section: P2 Receptor-mediated Responses Of Mast Cellsmentioning

confidence: 99%

Section: Purinergic Signaling In Allergic Airway Inflammation: Focus mentioning

confidence: 99%

See 3 more Smart Citations

P2 receptor-mediated signaling in mast cell biology

Bulanova

Bulfone–Paus∥

2009

Purinergic Signalling

101

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Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P₂ purinoceptors: Heterogeneity within P_2x and P_2y subtypes

Burnstock

Fischer

Hoyle

et al. 1994

Drug Development Research

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The structure-activity relationships for a variety of adenine nucleotide analogues at P 2x -and P 2Y -purinoceptors were investigated. Compounds formed by structural modifications of the ATP molecule including substitutions of the purine ring (C2, C8, N1, and N 6 -substituents, and a uridine base instead of adenine), the ribose moiety (2′ and 3′-positions), and the triphosphate group (lower phosphates, bridging oxygen substitution, and cyclization) were prepared. Pharmacological activity at P 2Y -purinoceptors was assayed in the guinea pig taenia coli, endothelial cells of the rabbit aorta, smooth muscle of the rabbit mesenteric artery, and turkey erythrocyte membranes. Activity at P 2X -purinoceptors was assayed in the rabbit saphenous artery and the guinea-pig vas deferens and urinary bladder. Some of the analogues displayed selectivity, or even specificity, for either the P 2X -or the P 2Y -purinoceptors. Certain analogues displayed selectivity or specificity within the P 2X -or P 2Y -purinoceptor superfamilies, giving hints about possible subclasses. For example, 8-(6-aminohexylamino)ATP and 2′,3′-isopropylidene-AMP were selective for endothelial Pzypurinoceptors over P 2Y -purinoceptors in the guinea pig taenia coli, rabbit aorta, and turkey erythrocytes. These compounds were both inactive at P 2X -purinoceptors. The potent agonist N 6 -methyl ATP and the somewhat less potent agonist 2′-deoxy-ATP were selective for P 2Y -purinoceptors in the guinea pig taenia coli, but were inactive at P 2X -purinoceptors and the vascular P 2Y -purinoceptors. 3′-Benzylamino-3′-deoxyATP was very potent at the P 2X -purinoceptors in the guinea pig vas deferens and bladder, but not in the rabbit saphenous artery and was inactive at P 2Y receptors. These data suggest that specific compounds can be developed that can be utilized to activate putative subtypes of the P 2X -and P 2Y -purinoceptor classes.

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Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets

et al. 1991

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Bile-canaliculus contraction in rat hepatocyte doublets is postulated to involve activation of an actinmyosin system. We examined this hypothesis by determining the relationship between canalicular contraction and cystolic free Ca2+ ([Ca2+]i) concentration after extracellular addition of ATP or microdialysis of myosin light chain kinase or its Ca2+-independent fragment, which retains catalytic activity. After incubation of doublets with 200 μmol/L ATP in the absence of extracellular Ca2+, [Ca2+]i peaked at 40 sec and 71% of canaliculi contracted within 4 min. Decreasing effects were observed with equimolar ADP, AMP and nonhydrolyzable ATP, but no effect was observed with adenosine. The effect of extracellular ATP on [Ca2+]i and canalicular contraction was dose dependent. Addition of extracellular Ca2+ and ATP resulted in a plateau level of [Ca2+]i. Cytochalasin D, which depolymerizes actin filaments, inhibited ATP-induced canalicular contraction, but not the increase in [Ca2+ Microdialysis of myosin light chain kinase and its Ca2+-independent fragment (but not the heatdenatured fragment, albumin, trypsin plus soybean inhibitor or buffer) into one hepatocyte of a doublet resulted in canalicular contraction in 86% of doublets. Injection of myosin light chain kinase or its Ca2+-independent fragment did not increase [Ca2+]i within 5 min. These results indicate that (a) the basolateral plasma membrane of hepatocytes has a P2Y-class purinoceptor, (b) increased [Ca2+]i after incubation with ATP is initially due to mobilization from internal sites and (c) canalicular contraction is directly related to [Ca2+]i and activation of an actin-myosin system. The physiological role of extracellular ATP in canalicular contraction is uncertain. (Hepatology 1991;14:640-647.)

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Activation and inhibition of calcium‐dependent histamine secretion by ATP ions applied to rat mast cells.

Cited by 145 publications

References 26 publications

P2 receptor-mediated signaling in mast cell biology

P2 receptor-mediated signaling in mast cell biology

Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P₂ purinoceptors: Heterogeneity within P_2x and P_2y subtypes

Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets

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Activation and inhibition of calcium‐dependent histamine secretion by ATP ions applied to rat mast cells.

Cited by 145 publications

References 26 publications

P2 receptor-mediated signaling in mast cell biology

P2 receptor-mediated signaling in mast cell biology

Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes

Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets

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Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P₂ purinoceptors: Heterogeneity within P_2x and P_2y subtypes