Activation by Inflammatory Stimuli Increases Neutrophil Binding of Human Immunodeficiency Virus Type 1 and Subsequent Infection of Lymphocytes

Gabali, Ali; Anzinger, Joshua J.; Spear, Gregory T.; Thomas, Larry L.

doi:10.1128/jvi.78.19.10833-10836.2004

Cited by 25 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this report, we provide further evidence that neutrophils are capable of binding, transferring, and thus spreading HIV-1, although they do so less efficiently than basophils. Neutrophil-mediated HIV-1 binding and transmission can be enhanced by tumor necrosis factor alpha (TNF-␣) stimulation (84).…”

Section: Discussionmentioning

confidence: 99%

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4⁺T Cells

Jiang

Guo

et al. 2015

J Virol

View full text Add to dashboard Cite

Granulocytes are a category of white blood cells (WBCs) characterized by the presence of lobulated nuclei and secretory granules in their cytoplasm. Blood-circulating granulocytes comprise mainly neutrophils, basophils, and eosinophils. Neutrophils make up the majority (50% to 60%) of circulating WBCs; basophils constitute only 0.5% to 1% and eosinophils less than 6%. Granulocytes are differentiated from bone marrow hematopoietic stem cells; they normally circulate in the bloodstream and are recruited to peripheral tissue under certain pathological conditions (1-5). Granulocytes participate in various inflammatory reactions. Basophils and eosinophils are known to modulate allergic disorders and autoimmune diseases (6-11).Granulocytes play crucial roles in combating invading pathogens. The expression by human granulocytes of a broad range of pattern recognition receptors suggests that they play a role in various forms of host innate immunity (12-14), and evidence is mounting that granulocytes are essential to the regulation of host adaptive immunity (6,15,16). Activated granulocytes release various intracellular granule proteins or cytokines to suppress or directly kill invading microbes and parasites (17)(18)(19)(20)(21)(22)(23)(24) or to recruit other host immune cells to combat pathogens. Neutrophils are "professional" phagocytes that rapidly engulf and degrade invaders or form extracellular traps to kill extracellular pathogens (23). Eosinophils have been described as capable of modulating the functions of other immune cells (16,25).The interplays between granulocytes and HIV-1 and their contribution to HIV-1 disease progression remain elusive. The majority of peripheral blood neutrophils do not express CD4 molecules on their surface. Previous work showed that 4 of 51 (7.8%) HIV-1-infected individuals and 3 of 25 (12%) uninfected individuals had CD4 expression on their peripheral blood neutrophils

show abstract

Section: Discussionmentioning

confidence: 99%

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4⁺T Cells

Jiang

Guo

et al. 2015

J Virol

View full text Add to dashboard Cite

show abstract

“…The molecular conformation of PMN-expressed CD4 is very similar to that of CD4 expressed on the surface of lymphocytes, and CD4+ PMN have been shown to bind HIV-1 gp120 [38]. HIV-1 binding has also been reported on the surface of CD4-negative PMN, independently of gp120 [16]. In addition, PMN constitutively express CXCR4 and may selectively bind X4 strains of HIV [39].…”

Section: Hiv-1 Binds To Pmn: Implications For Hiv-1 Transmissionmentioning

confidence: 99%

“…PMN-bound HIV-1 virions have been shown to infect activated PBMC and to transfer the infection to lymphocytes more efficiently than free HIV-1 [16,42]. Furthermore, HIV binding to PMN is enhanced by inflammatory stimuli produced by T lymphocytes, such as TNF-α, in turn increasing the rate of PBMC infection [16].…”

Section: Hiv-1 Binds To Pmn: Implications For Hiv-1 Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Interactions between Human Immunodeficiency Virus Type 1 and Polymorphonuclear Neutrophils

Casulli¹,

Elbim²

2013

J Innate Immun

View full text Add to dashboard Cite

Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.

show abstract

“…It has been demonstrated that HIV can bind to resting and activated neutrophils, which then may transfer the virus to uninfected cells (13,28). Furthermore, there remains the potential that HIV complexed with bispecific antibody may be redirected to other CD89-positive (CD89 ϩ ) cells (such as monocytes), resulting in the transmission of infection.…”

mentioning

confidence: 99%

A Bispecific Antibody Composed of a Nonneutralizing Antibody to the gp41 Immunodominant Region and an Anti-CD89 Antibody Directs Broad Human Immunodeficiency Virus Destruction by Neutrophils

Duval

Posner

Cavacini

2008

J Virol

View full text Add to dashboard Cite

In addition to the direct neutralization of virus, there is a broader potential for antibody-mediated inhibition of human immunodeficiency virus (HIV) by targeting HIV to effector cells. We demonstrate here that a bispecific antibody incorporating a broadly reactive anti-gp41 antibody, F240, and an anti-IgA receptor (CD89) antibody is effective at directing neutrophils to destroy HIV. Not only are neutrophils the predominant type of white blood cells and very efficient at mediating cell cytotoxicity, they are relatively resistant to infection with HIV. Therefore, they represent a significant weapon against infection if they can be directed and armed to destroy HIV and infected cells.

show abstract

Activation by Inflammatory Stimuli Increases Neutrophil Binding of Human Immunodeficiency Virus Type 1 and Subsequent Infection of Lymphocytes

Cited by 25 publications

References 25 publications

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4⁺T Cells

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4⁺T Cells

Interactions between Human Immunodeficiency Virus Type 1 and Polymorphonuclear Neutrophils

A Bispecific Antibody Composed of a Nonneutralizing Antibody to the gp41 Immunodominant Region and an Anti-CD89 Antibody Directs Broad Human Immunodeficiency Virus Destruction by Neutrophils

Contact Info

Product

Resources

About

Activation by Inflammatory Stimuli Increases Neutrophil Binding of Human Immunodeficiency Virus Type 1 and Subsequent Infection of Lymphocytes

Cited by 25 publications

References 25 publications

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4+T Cells

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4+T Cells

Interactions between Human Immunodeficiency Virus Type 1 and Polymorphonuclear Neutrophils

A Bispecific Antibody Composed of a Nonneutralizing Antibody to the gp41 Immunodominant Region and an Anti-CD89 Antibody Directs Broad Human Immunodeficiency Virus Destruction by Neutrophils

Contact Info

Product

Resources

About

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4⁺T Cells

Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4⁺T Cells