In the present investigation, Soret–Dufour and multislip's impact on magnetohydrodynamics (MHD) Casson fluid flow encompassing variable thermophysical features in the nonlinear convection process is analyzed. It is believed that to any effective heat and mass transfer enhancement, the relaxation of such fluid and material time along with the thermo‐physical features, are well estimated. In this model, a magnetic field of nonuniform strength is applied perpendicular to the slendering sheet with variable thickness, and nonlinear convection flow is considered in this generalized heat flux examination. An appropriate similarity variable is implemented on the governing equations embedding the variable viscosity, thermal conductivity, and generalized Fourier's law to drive ordinary differential equations. Galerkin weighted residual approach is utilized to calculate the flow field among other flow characteristics. The novel flow features are discussed therein. Modified Fourier and multislip's parameters are seen to have downsized the velocity and temperature field greatly. Thermal and solutal buoyancy effects are more pronounced in nonlinear form compared to the linear model. Dufour number influences both velocity and energy fields positively but negates the concentration field, while the Soret number gives an opposing characterization.